Code | CSB-RA953976A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (αβ and γδ), NK cells, and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. Upon acute immune activation, such as infection, CD27/CD70 co-stimulation stimulates the clonal expansion of antigen-specific T cells and is required to establish T cell memory, amongst others by promoting the survival of activated T cells. Furthermore, CD27/CD70 co-stimulation facilitates the survival of effector T cells in non-lymphoid tissues by stimulating their autocrine interleukin (IL)-2 production.
The main production processes of this recombinant CD27 antibody included immunization, B cell harvest, antibody secreting cell enrichment, single cell sequencing, antibody expression and purification. The single B cell screening platform was used for the CD27 antibody gene screening. And this CD27 antibody was tested in ELISA, WB.There are currently no reviews for this product.