Recombinant Human Erlin-2(ERLIN2)

Code CSB-CF007791HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O94905
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDEPLETATKEN
Source in vitro E.coli expression system
Gene Names ERLIN2
Protein Names Recommended name: Erlin-2 Alternative name(s): Endoplasmic reticulum lipid raft-associated protein 2 Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 Short name= SPFH domain-containing protein 2
Expression Region 1-339
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1
Involvement in disease Spastic paraplegia 18, autosomal recessive (SPG18)
Subcellular Location Endoplasmic reticulum membrane, Single-pass type II membrane protein
Protein Families Band 7/mec-2 family
Tissue Specificity Ubiquitous.
Database Links

HGNC: 1356

OMIM: 611225

KEGG: hsa:11160

STRING: 9606.ENSP00000276461

UniGene: Hs.705490

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