Recombinant Human G protein-activated inward rectifier potassium channel 2 (KCNJ6)

1. The KCNJ6 -1250A and COMT Val alleles are predisposing preterm newborns to diminished opioid-induced pain relief. PMID: 27027462
2. The major findings of the current study are 1) an additive genotypic effect of the KCNJ6 SNP on the ERO theta power phenotype during reward processing, increasing significantly across genotypes. PMID: 27993610
3. Three of the four KCNJ6 SNPs studied here were found to be significantly associated with the same theta event related oscillations in adults. PMID: 27847216
4. The findings of this study suggest that variations in KCNJ6 genes are associated with both mild and severe persistent breast pain after breast cancer surgery. PMID: 25599232
5. KCNJ6 (GIRK2) gene polymorphism rs2835859 could serve as a marker that predicts sensitivity to analgesics and pain and susceptibility to nicotine dependence. PMID: 25346042
6. In this transgenic mouse model, GIRK2 plays a major role in the genesis of infantile spasms. PMID: 26032891
7. Keppen-Lubinsky syndrome is caused by mutations in the inwardly rectifying K+ channel encoded by KCNJ6. PMID: 25620207
8. For KCNJ6, three SNPs (i.e., rs2835914, rs8129919, rs2836050) were associated with the occurrence of preoperative breast pain. PMID: 24392765
9. Eight KCNNJ6 single nucleotide polymorphisms(SNPs) are significantly associated with pain-related phenotypes. PMID: 23994450
10. Ethanol associates directly with the GIRK channel, leading to enhanced interaction with a membrane phospholipid phosphatidylinositol 4,5-bisphosphate and activation of the channel. PMID: 24145411
11. 3.5 A resolution crystal structure of the mammalian GIRK2 channel in complex with betagamma G-protein subunits, the central signalling complex that links G-protein-coupled receptor stimulation to K(+) channel activity PMID: 23739333
12. KCNJ6 (or its product GIRK2) accounts for some of the variations in frontal theta; band oscillations. PMID: 22554406
13. Conformational information encoded by ligand binding to delta-opioid receptors (DORs) is transmitted to Kir3.1/Kir3.2 channels. PMID: 23175530
14. GIRK2 is expressed in nearly every human pigmented neuron or mouse tyrosine hydroxylase-immunoreactive neuron in both the substantia nigra and ventral tegmental areas. PMID: 22252428
15. GIRK overexpression in Ts65Dn mice has functional consequences affecting balance between GABA(A) and GABA(B) inhibition of CA1 pyramidal neurons in a pathway specific manner, that may contribute to cognitive deficits in Ts65 mouse model of Down syndrome. PMID: 22178330
16. KCNJ6 is associated with alcohol dependence and may moderate the effect of early psychosocial stress on risky alcohol drinking in adolescents PMID: 21307845
17. The KCNJ6 promoter is activated by Trichostatin A (TSA) treatment and by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
18. significant interaction between the TT genotype of rs2070995 (located in KCNJ6) and the GG genotype of rs2253206 (located in CREB1) on rumination were found PMID: 20943350
19. The overexpression of one particular gene encoding for G-protein-activated inward rectifying potassium type 2 (GIRK2) channel subunit and its coupling to GABA(B) receptors may contribute to a range of mental and functional disabilities in Down syndrome. PMID: 20655490
20. KCNJ6 (GIRK2) gene polymorphisms have roles in postoperative analgesic requirements after major abdominal surgery PMID: 19756153
21. L344 and G347 play an important functional role in G(betagamma) activation of GIRK2 channels. PMID: 14724209
22. The potential synergy and consequences of the overexpression of KIR3.2 and KIR4.2 in Down's syndrome brain development are discussed. PMID: 15068243
23. Decreased GRK 2 expression most likely results from reduced cAMP stimulation in cold thyroid nodules. PMID: 15772902
24. These data suggest that KCNJ6 could play an important role in altered cardiac regulation in Down syndrome patients. PMID: 18303085
25. Kir3.2 was capable of interacting with Gbeta1-3 and not Gbeta4 or Gbeta5. These interactions were again fostered by co-expression with Ggamma and were also insensitive to DN Sar 1 or Rab 1. PMID: 19135528

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HGNC: 6267

OMIM: 600877

KEGG: hsa:3763

STRING: 9606.ENSP00000288309

UniGene: Hs.626242