Recombinant Human Tumor necrosis factor receptor superfamily member 10A(TNFRSF10A)

Code CSB-CF023964HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O00220
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence ASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
Source in vitro E.coli expression system
Gene Names TNFRSF10A
Protein Names Recommended name: Tumor necrosis factor receptor superfamily member 10A Alternative name(s): Death receptor 4 TNF-related apoptosis-inducing ligand receptor 1 Short name= TRAIL receptor 1 Short name= TRAIL-R1 CD_antigen= CD261
Expression Region 24-468
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor for the cytotoxic ligand TNFSF10/TRAIL
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
Database Links

HGNC: 11904

OMIM: 603611

KEGG: hsa:8797

STRING: 9606.ENSP00000221132

UniGene: Hs.213467

Pathway Apoptosis
Necroptosis
Natural killer cell mediated cytotoxicity

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