The following TNFRSF10A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TNFRSF10A Antibodies

TNFRSF10A Antibodies for Homo sapiens (Human)

TNFRSF10A Proteins

TNFRSF10A Proteins for Homo sapiens (Human)

TNFRSF10A Background

Tumor necrosis factor receptor superfamily member 10A is a protein in humans that is encoded by the TNFRSF10A gene. It is a member of the TNF-receptor superfamily. TNFRSF10A is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis, thus transduces cell death signal and induces cell apoptosis. It also promotes the activation of NF-kappa-B. Studies with FADD-deficient mice suggested that FADD, a death domain-containing adaptor protein, is required for the apoptosis mediated by this protein.

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