TNFRSF10A Research Reagents

TNFRSF10A Background

Tumor necrosis factor receptor superfamily member 10A is a protein in humans that is encoded by the TNFRSF10A gene. It is a member of the TNF-receptor superfamily. TNFRSF10A is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis, thus transduces cell death signal and induces cell apoptosis. It also promotes the activation of NF-kappa-B. Studies with FADD-deficient mice suggested that FADD, a death domain-containing adaptor protein, is required for the apoptosis mediated by this protein.