Recombinant Human Tumor necrosis factor receptor superfamily member 1B(TNFRSF1B)

Code CSB-CF023978HU
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P20333
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Sequence LPAQVAFTPYAPEPGSTCRLREYYDQTAQMCCSKCSPGQHAKVFCTKTSDTVCDSCEDSTYTQLWNWVPECLSCGSRCSSDQVETQACTREQNRICTCRPGWYCALSKQEGCRLCAPLRKCRPGFGVARPGTETSDVVCKPCAPGTFSNTTSSTDICRPHQICNVVAIPGNASMDAVCTSTSPTRSMAPGAVHLPQPVSTRSQHTQPTPEPSTAPSTSFLLPMGPSPPAEGSTGDFALPVGLIVGVTALGLLIIGVVNCVIMTQVKKKPLCLQREAKVPHLPADKARGTQGPEQQHLLITAPSSSSSSLESSASALDRRAPTRNQPQAPGVEASGAGEARASTGSSDSSPGGHGTQVNVTCIVNVCSSSDHSSQCSSQASSTMGDTDSSPSESPKDEQVPFSKEECAFRSQLETPETLLGSTEEKPLPLGVPDAGMKPS
Source in vitro E.coli expression system
Gene Names TNFRSF1B
Protein Names Recommended name: Tumor necrosis factor receptor superfamily member 1B Alternative name(s): Tumor necrosis factor receptor 2 Short name= TNF-R2 Tumor necrosis factor receptor type II Short name= TNF-RII Short name= TNFR-II p75 p80 TNF-a
Expression Region 23-461
Tag Info 10xHis-SUMO-tag
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted
Database Links

HGNC: 11917

OMIM: 191191

KEGG: hsa:7133

STRING: 9606.ENSP00000365435

UniGene: Hs.256278

Pathway TNF signaling pathway
Adipocytokine signaling pathway

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