Recombinant Human Tumor necrosis factor receptor superfamily member 1B protein(TNFRSF1B) (Active)

In Stock
Code CSB-AP002371HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P20333
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-α mediated cytotoxicity in the L-929 cells is less than 0.2 μg/ml, corresponding to a specific activity of >5000 IU/mg in the presence of 0.25 ng/mL of rHuTNF-α.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence M+PAQVAFTPY APEPGSTCRL REYYDQTAQM CCSKCSPGQH AKVFCTKTSD TVCDSCEDST YTQLWNWVPE CLSCGSRCSS DQVETQACTR EQNRICTCRP GWYCALSKQE GCRLCAPLRK CRPGFGVARP GTETSDVVCK PCAPGTFSNT TSSTDICRPH QICNVVAIPG NASMDAVCTS TSPT
Research Area Cancer
Source E.coli
Gene Names TNFRSF1B
Expression Region 23-206aa
Tag Info Tag-Free
Mol. Weight 20.0 kDa
Protein Description Partial
PubMed ID 2172983; 2160731; 8661109; 14688072; 16710414; 15489334; 2173696; 8015639; 2153136; 1966549; 2166946; 11197692; 1328224; 8069916; 12370298; 25456591; 10206649; 11762942; 12161545
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Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted, SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted
Database Links

HGNC: 11917

OMIM: 191191

KEGG: hsa:7133

STRING: 9606.ENSP00000365435

UniGene: Hs.256278

Pathway TNF signaling pathway
Adipocytokine signaling pathway

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