Recombinant Mouse 5-hydroxytryptamine receptor 1B (Htr1b)

1. Consistent with previous studies that have optogenetically inhibited vHPC-mPFC projections, activating prefrontal 5-HT1B receptors suppressed theta-frequency mPFC activity (4-12 Hz), and reduced avoidance of anxiogenic regions in the elevated plus maze PMID: 27974203
2. Mice lacking 5-HT1B autoreceptors displayed the expected increases in extracellular serotonin levels in the ventral hippocampus following administration of a selective serotonin reuptake inhibitor. PMID: 27353308
3. 5-HT1B receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in pulmonary arterial hypertension. PMID: 28473438
4. 5-HT1B Knockout and pharmacologic 5-HT1B antagonism both attenuated locomotor hyperactivity in dopamine transporter Knockout mice. PMID: 25514162
5. 5-HT1BR was validated as a target for miRNA-96. Transfection of precursor miRNA-96 into hPASMCs reduced 5-HT1BR expression and inhibited serotonin-induced proliferation in pulmonary hypertension development. PMID: 25871906
6. The data of this study showed that while adolescent expression of 5-HT1BRs influences aggressive behavior, a distinct set of 5-HT1B receptors modulates impulsive behavior during adulthood. PMID: 25892302
7. 5-HT(1B)R stimulation increased glutamatergic neurotransmission in the hippocampus in p11KO mice, but not in WT mice. Hippocampal p11 determines the directionality of 5-HT(1B)R action on emotional memory processing PMID: 23032875
8. Selective inhibition of 5-HT2A by sarpogrelate stimulated angiogenesis, restoring ischemic limb blood perfusion in a severe diabetic mouse model through stimulation of the eNOS/Akt pathway via the endothelial 5-HT1B receptor. PMID: 22172591
9. Data indicate that most p11 expressing cells in cerebral cortex, hippocampus, cerebellum, & caudate-putamen express HTR1B or co-express HTR1B/HTR4, suggesting crucial role for p11 in modulating actions of serotonin via these receptor subtypes. PMID: 21300076
10. In the developing barrel field of the neonatal mice 5-HT1B receptors mediate an activity-dependent regulation of the thalamocortical EPSC that could favor the propagation of high-frequency thalamocortical activity PMID: 11826118
11. 5-Hydroxytryptamine(1B/1D) receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. PMID: 12110114
12. endogenous activation of 5-HT1B presynaptic receptors modulates circadian behavior by attenuating photic input to the suprachiasmatic nucleus PMID: 12375619
13. The influence of the pre- and postweaning maternal environment on the offspring's phenotype was examined in 5-HT1A and 5-HT1B receptor knockout mice (KO1A and KO1B, respectively. PMID: 12555283
14. Serotonin 1B receptor gene deletion selectively enhances learning performance when the cognitive requirement of the task is elevated. PMID: 12565126
15. 5-HT(1B) receptors appear to play an important role in impulsivity and a minor role in prefrontal cortex-dependent learning and memory as shown by the results obtained in serial reversal learning and extinction PMID: 12742250
16. Delay-dependent working memory is impaired in young-adult and aged 5-HT1B knockout mice PMID: 14557613
17. These studies revealed a beneficial effect of the mutation on the acquisition of a spatial reference memory task, but a deleterious effect on a working memory task for long delays. PMID: 14657258
18. Presynaptic serotonergic modulation of the retinogeniculate synapse occurred primarily through 5-HT1B receptors, resulting in inhibition of synaptic release and relief of synaptic depression. PMID: 15574745
19. PrPC is a modulator of 5-HT receptor coupling to G-proteins and contributes to the homeostasis of serotonergic neurons PMID: 15590675
20. results of the present study indicate that the dynamic modulation of 5-HT1B receptor function by p11 may be involved in molecular adaptations occurring in neuronal networks that are dysfunctional in depression-like states PMID: 16400147
21. Knockout mice show changes in the increase in cortical serotonin outflow caused by systemic injection of paroxetine compared with normal mice. PMID: 16433012
22. role of 5-HT1B receptors in photic entrainment PMID: 16461982
23. Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity. PMID: 17420766
24. Early-weaned mice were more aggressive after food restriction stress than were the normally weaned mice and had lower 5HT1B expression. PMID: 18022705
25. These results suggest that 5-HT(1B) receptors in the mPFC may serve to selectively disinhibit aggressive behavior in mice with a history of Alc self-administration. PMID: 18305458
26. Increases in D2 binding sites, presumably involving GABAergic projection neurons, were measured in the nucleus accumbens, olfactory tubercle and ventral tegmental area of the 5-HT1B KO. PMID: 18406571
27. is a neurochemical basis for the behavioral sensitization. PMID: 18516987
28. These results show that a prenatal 5-HT excess affects, via the overactivation of 5-HT(2A)-R, the expression of 5-HT(1B)-R in phrenic motor neurons and the organization of their premotor network. PMID: 18783379

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KEGG: mmu:15551

STRING: 10090.ENSMUSP00000050898

UniGene: Mm.445308