Recombinant Mouse Adenosine receptor A1(Adora1)

Code CSB-CF723331MO
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Adora1
Uniprot No. Q60612
Alternative Names Adora1Adenosine receptor A1
Species Mus musculus (Mouse)
Expression Region 1-326
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

(From Uniprot)
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Gene References into Functions
  1. Loss of A1AR expression results in an increased susceptibility to noise-induced cochlear neural injury and hearing loss. PMID: 28034618
  2. Expression of the SENP2 gene was suppressed by theobromine. In vivo knockdown studies showed that AR1 knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPbeta degradation by increasing its sumoylation. PMID: 28965824
  3. The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings. PMID: 27339059
  4. Systemic inflammatory response syndrome-associated lymphopenia is initiated by A1R desensitization and adenosine-mediated inhibition of IL-15 production is part of the mechanism that accounts for the delay in leukopenia recovery in patients with severe sepsis. PMID: 28495790
  5. Results demonstrated a significant downregulation of adenosine A1 receptors in the cortex and striatum, concomitant to striatal D2R downregulation in iron deficient mice and rats. PMID: 27600688
  6. Adenosine A1A receptor and adenosine A3A receptor agonists and adenosine 5'-monophosphate cause regulated hypothermia that was characterized by a drop in total energy expenditure, physical inactivity, and preference for cooler environmental temperatures, indicating a reduced body temperature set point. PMID: 27914963
  7. over-expression of sEH enhances A1AR-dependent contraction and reduces KATP channel-dependent relaxation in MAs. These results suggest a possible interaction between sEH, A1AR, and KATP channels in regulating vascular tone. PMID: 27629787
  8. Results indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice PMID: 26593641
  9. The findings of this study implicated a glial-neuronal circuit, mediated by Ado, neuronal AdoRA1, and glial AdK that can modulate sleep homeostasis in a manner influenced by glial metabolic state. PMID: 27030757
  10. Chronic cerebral ischemia in a mouse model induced down-regulation of adenosine A1 receptors. PMID: 25982512
  11. Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration PMID: 26964090
  12. A1 receptors regulate metabolism and islet endocrine and vascular functions during ageing PMID: 25835725
  13. Adenosine A1 receptor knockout mice displayed increased depressive-like behavior. PMID: 26247862
  14. data support the interpretation that adenosine A receptors localized to the pontine reticular formation significantly alter nociception. PMID: 24976513
  15. did not identify phenotypic modifications of A1AR-related effects on blood pressure, heart rate and plasma renin by differences in genetic background PMID: 25182861
  16. Interaction between angiotensin II and adenosine in VSMC normally involves A1 receptor signalling PMID: 25251152
  17. Extracellular cAMP, through its metabolite adenosine, reduced cardiomyocyte cAMP formation and hypertrophy by activating A1 adenosine receptors while delivering an antifibrotic signal to cardiac fibroblasts by A2 adenosine receptor activation. PMID: 25401477
  18. NPS evokes central antinociceptive effects by activating both A1 and A2A receptors during phase 1, but only the adenosine A2A receptor during phase 2 of the formalin test PMID: 25447449
  19. These findings indicate that adenosine activation of leukocyte adenosine A1 receptor plays a significant role in their recruitment to the infected lung and contributes to influenza pathogenesis. PMID: 24965449
  20. The A1 adenosine receptor may play a role in the development of atherosclerosis PMID: 24525840
  21. A1ARs mediate in utero caffeine effects on cardiac function and growth and that caffeine exposure leads to changes in DNA methylation. PMID: 24475304
  22. Adenosin inhibited Lipopolysaccharide-increased HIF1alpha accumulation under both normoxic and hypoxic conditions, through activation of A1 and A3 adenosine receptors. PMID: 23969284
  23. These results indicate that inosine possesses an antidepressant-like effect probably through the activation of adenosine A1 and A2A receptors PMID: 23613131
  24. Suggest that A1 adenosine receptor counteracts the A2A AR-mediated coronary flow increase during reactive hyperemia. PMID: 24043252
  25. The splicing of Adora1 and loss of Adora1 expression on alpha-cells may explain the hyperglucagonemia observed in prediabetic NOD mice and may contribute to the pathogenesis of human type 1 diabetes. PMID: 24264405
  26. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors. PMID: 23682121
  27. Endogenous A1A receptor activation protects against acute ethanol-induced liver injury by reducing oxidative stress. PMID: 23692951
  28. An important role was determined for adenosine A1 receptors in RANKL-induced osteoclastogenesis. PMID: 22311477
  29. tested whether induction of cytoprotective sphingosine kinase-1 and sphingosine-1-phosphate synthesis might be the mechanism in A1 adenosine receptor-mediated renal protection from ischemia PMID: 22695326
  30. these results show that ADORA1 is enriched on neuron cells where it functions to control norepinephrin release. Activation of this receptor during penile erection results in reduced norepinephrin release and reduced cavernosal smooth muscle contraction, therefore facilitating penile erection. PMID: 22862844
  31. The presented data provide for the first time direct evidence that the upregulation of A(1)R enhances neuronal survival. PMID: 22899189
  32. The increase in blood pressure seen in A(1)-AR knockout mice is lower than that seen in wild-type mice but was increased by ANG II nonetheless. The presence of A(1)-ARs during a low dose of ANG II-infusion limits Na(+) and phosphate excretion. PMID: 22874421
  33. It was shown that adenosine A(1) receptors in the pancreas are involved in regulating the temporal patterns of insulin release. PMID: 22550063
  34. Data suggest that expression of Adora1 is too low to play a major role in regulation of lipogenic gene expression in hepatocytes; these results are in contrast to the high expression of Adora1 in cerebral cortex. PMID: 22449383
  35. caffeine alters embryonic cardiac function and disrupts the normal cardiac response to hypoxia through blockade of A1AR action PMID: 22164264
  36. The data suggested that, in the absence of A2A adenosine receptor, omega-hydroxylase induces vasoconstriction through mitogen-activated protein kinases via upregulation of adenosine A1 receptor and protein kinase C-alpha. PMID: 22160543
  37. AMP and a non-hydrolyzable AMP analog (deoxyadenosine 5'-monophosphonate, ACP) directly activated the adenosine A(1) receptor PMID: 22215671
  38. Adenosine can negatively regulate mouse duodenal motility either by activating A1 inhibitory receptors located post-junctionally or controlling neurotransmitter release via A1 or A2A receptors. PMID: 21615720
  39. pacemaking and conduction disturbances are induced via A(1)AR through concomitant stimulation of NADPH oxidase and PLC, followed by downstream activation of ERK and PKC with LCC as possible target. PMID: 21907719
  40. It was concluded that adenosine A(1)-receptors enhance preglomerular responses during NO inhibition and ANG II treatment. PMID: 21975649
  41. A1AR signaling contributes importantly to insulin-controlled glucose homeostasis and insulin sensitivity in C57BL/6 mice and is involved in the metabolic regulation of adipose tissue. PMID: 21831968
  42. results suggest that AR signaling represents a novel, endogenous modulator of BBB permeability. PMID: 21917810
  43. Both adenosine A(2A) and A(2B) receptors are required for adenosine A(1) receptor-mediated cardioprotection, implicating a role for interactions among receptor subtypes. PMID: 21743001
  44. Data suggest that adenosine deficiency may be relevant to human epilepsy and that a ketogenic diet can reduce seizures by increasing adenosine A1 receptor-mediated inhibition. PMID: 21701065
  45. Matrix metalloproteinase-mediated EGFR activation appears essential to cardiac protection and signaling via A1 adenosine receptors and preconditioning. PMID: 21460200
  46. A(1) and A(2B) receptors are both involved in differentiation to Treg, but through different mechanisms. PMID: 21557932
  47. these results suggest that A1 receptor-mediated signaling regulates EAAT2 expression in astrocytes. PMID: 21291865
  48. The results of this study suggested that both A1 as well as A2A receptor antagonists could be useful therapeutically to lower the risk of L-DOPA-induced dyskinesia in parkinson disease patients PMID: 20828543
  49. Adenosine A1 receptor-mediated inhibition of ghrelin release from the stomach is apparent when the tonic excitatory effect of adenosine is removed from the isolated perfused gastric mucosa. PMID: 20876230
  50. Data show that adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent reward-aversion effects. PMID: 20576036

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Database Links

KEGG: mmu:11539

STRING: 10090.ENSMUSP00000043522

UniGene: Mm.298908


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