ADORA1

Adenosine A1 Receptor (ADORA1), encoded by the ADORA1 gene, is a G protein-coupled receptor (GPCR) also known as adenosine receptor A1. It couples to Gi/o proteins, inhibiting adenylyl cyclase and reducing intracellular cyclic adenosine monophosphate (cAMP) levels. This modulates neuronal excitability via potassium channel activation and calcium mobilization suppression, regulating neurotransmitter release.
ADORA1 is implicated in sleep regulation (agonists promote sleep), neuroprotection in ischemic stroke/Alzheimer’s, and antinociception. Drug development includes selective agonists like capadenoson (phase II trials for atrial fibrillation) and antagonists targeting cognitive deficits, though clinical progress is limited by off-target effects.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ADORA1 Recombinant Monoclonal Antibody (CSB-RA224168A0HU)

Validated Data

Western Blot
Positive WB detected in: A549 whole cell lysate, 293 whole cell lysate, U87 whole cell lysate
All lanes: ADORA1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 37, 14 kDa
Observed band size: 37 kDa

IHC image of CSB-RA224168A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ADORA1 Antibody (CSB-PA001375EA01HU)

Validated Data

Immunofluorescent analysis of Hela cells using CSB-PA001375EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following ADORA1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ADORA1 Antibodies

ADORA1 Proteins

ADORA1 Antibodies

ADORA1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA001375GA01HU	ADORA1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA007162	ADORA1 Antibody	Human,Rat	WB, IF, ELISA
CSB-PA001375EA01HU	ADORA1 Antibody	Human	ELISA, IF
CSB-RA224168A0HU	ADORA1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC

ADORA1 Proteins

ADORA1 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-CF001375CH	Recombinant Chicken Adenosine receptor A1 (ADORA1)	in vitro E.coli expression system
CSB-YP001375CH1 CSB-EP001375CH1 CSB-BP001375CH1 CSB-MP001375CH1 CSB-EP001375CH1-B	Recombinant Chicken Adenosine receptor A1 (ADORA1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADORA1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF723331MO	Recombinant Mouse Adenosine receptor A1 (Adora1)	in vitro E.coli expression system
CSB-YP723331MO1 CSB-EP723331MO1 CSB-BP723331MO1 CSB-MP723331MO1 CSB-EP723331MO1-B	Recombinant Mouse Adenosine receptor A1 (Adora1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADORA1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-CF735863PYX	Recombinant Pongo abelii Adenosine receptor A1 (ADORA1)	in vitro E.coli expression system
CSB-YP735863PYX1 CSB-EP735863PYX1 CSB-BP735863PYX1 CSB-MP735863PYX1 CSB-EP735863PYX1-B	Recombinant Pongo abelii Adenosine receptor A1 (ADORA1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADORA1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-CF001375DO	Recombinant Dog Adenosine receptor A1 (ADORA1)	in vitro E.coli expression system
CSB-YP001375DO1 CSB-EP001375DO1 CSB-BP001375DO1 CSB-MP001375DO1 CSB-EP001375DO1-B	Recombinant Dog Adenosine receptor A1 (ADORA1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADORA1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF001375BO	Recombinant Bovine Adenosine receptor A1 (ADORA1)	in vitro E.coli expression system
CSB-YP001375BO1 CSB-EP001375BO1 CSB-BP001375BO1 CSB-MP001375BO1 CSB-EP001375BO1-B	Recombinant Bovine Adenosine receptor A1 (ADORA1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADORA1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF001375HU	Recombinant Human Adenosine receptor A1 (ADORA1)	in vitro E.coli expression system
CSB-YP001375HU1 CSB-EP001375HU1 CSB-BP001375HU1 CSB-MP001375HU1 CSB-EP001375HU1-B	Recombinant Human Adenosine receptor A1 (ADORA1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP001375HU	Recombinant Human Adenosine receptor A1 (ADORA1)-VLPs	Mammalian cell

ADORA1 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-CF001375GU	Recombinant Guinea pig Adenosine receptor A1 (ADORA1)	in vitro E.coli expression system
CSB-YP001375GU1 CSB-EP001375GU1 CSB-BP001375GU1 CSB-MP001375GU1 CSB-EP001375GU1-B	Recombinant Guinea pig Adenosine receptor A1 (ADORA1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADORA1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF001375RA	Recombinant Rat Adenosine receptor A1 (Adora1)	in vitro E.coli expression system
CSB-YP001375RA1 CSB-EP001375RA1 CSB-BP001375RA1 CSB-MP001375RA1 CSB-EP001375RA1-B	Recombinant Rat Adenosine receptor A1 (Adora1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ADORA1 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-CF001375RB	Recombinant Rabbit Adenosine receptor A1 (ADORA1)	in vitro E.coli expression system
CSB-YP001375RB1 CSB-EP001375RB1 CSB-BP001375RB1 CSB-MP001375RB1 CSB-EP001375RB1-B	Recombinant Rabbit Adenosine receptor A1 (ADORA1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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ADORA1

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