Recombinant Mouse Protein Dihydroorotate dehydrogenase (quinone), mitochondrial(Dhodh)

In Stock
Code CSB-CF006852MO
Size US$3521
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 85% as determined by SDS-PAGE.
Target Names Dhodh
Uniprot No. O35435
Research Area Metabolism
Alternative Names Dhodh; Dihydroorotate dehydrogenase; quinone); mitochondrial; DHOdehase; EC; Dihydroorotate oxidase
Species Mus musculus (Mouse)
Source in vitro E.coli expression system
Expression Region 11-395aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 44.2 kDa
Protein Length Full Length of Mature Protein
Tag Info C-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

Function Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Gene References into Functions
  1. DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in mouse xenograft studies PMID: 21430780
  2. immunosuppressive agent HR325 (an inhibitor of dihydroorotate dehydrogenase, DHODH) inhibits immunoglobulin (Ig) secretion both in vitro and in vivo and that this effect can be reverse with exogenous uridine PMID: 12100469
  3. Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells of different species PMID: 15571246
Subcellular Location Mitochondrion inner membrane, Single-pass membrane protein
Protein Families Dihydroorotate dehydrogenase family, Type 2 subfamily
Database Links

KEGG: mmu:56749

STRING: 10090.ENSMUSP00000070303

UniGene: Mm.23894


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