Recombinant Mouse Prostacyclin receptor (Ptgir)

1. results provide evidence that PGI2/IP signaling suppresses the STAT6-independent pathway of allergic airway inflammation PMID: 27456482
2. Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (Ptgir) is involved in insulin secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin. PMID: 26868296
3. Deletion of the I prostanoid receptor had no effect on the attenuation of atherogenesis by mPGES-1 deletion in the low-density lipoprotein receptor knockout mice. PMID: 27440004
4. Prostacyclin promotes the up-regulation of Nox4 in endothelial cells, which opens up a novel strategy that protects and enhances endothelial cell functions in cardiovascular disease, such as repair after myocardial infarction or other ischemic conditions. PMID: 24450852
5. Its signaling increase cAMP concentration, which prototes sysnesis of HGF, causing angiogenesis. PMID: 24292413
6. an essential role of the COX-2/PGI2 receptor axis in the cardioprotection afforded by the late ischemic preconditioning PMID: 22844439
7. findings suggest the IP receptor might maintain an angiogenic switch in the "on" state in tumor endothelial cells (TEC); suggest that the IP receptor is a TEC-specific marker and might be a useful therapeutic target PMID: 22380928
8. PGI2-induced PPAR delta activation accelerates blastocyst hatching in mice PMID: 21511721
9. For the first time these results show that activation of prostaglandin I2 receptor can attenuate damage following cerebral ischemia. PMID: 20621166
10. identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4(+) Th2 cells into the inflammatory site PMID: 17947695
11. The prostacyclin/IP pathway suppresses cardiac fibrosis, at least partly, by inducing CREB phosphorylation. PMID: 20403362
12. Prostaglandin I2 receptor signaling promotes T helper cell type (Th)1 differentiation through a cyclic adenosine monophosphate (AMP)-protein kinase A pathway, thereby initiating acquired cutaneous immune responses. PMID: 20400695
13. The prostaglandin I(2)-IP system is essential for EPCs to accomplish their function and plays a critical role in the regulation of vascular remodeling. PMID: 20007911
14. Results identify the cyclooxygenase-2 gene as a target of APOE signaling, link HDL and APOE to prostacyclin receptor IP action, and describe a potential new basis for the cardioprotective effect of HDL and APOE. PMID: 14966570
15. results suggest that signaling through IP has antiviral effects while protecting against respiratory syncytial virus-induced illness PMID: 15367596
16. The -CSLC motif of the IP is a direct target for inhibition by the FTI SCH66336, and in the presence of strong farnesyltransferase inhibition, the IP does not undergo compensatory geranylgeranylation. PMID: 15469414
17. Baseline systolic blood pressurewas significantly lower in the IP(-/-) group than in the IP(+/+) mice. PMID: 15635218
18. IP plays a suppressive role in the development of pressure overload-induced cardiac hypertrophy via the inhibition of both cardiomyocyte hypertrophy and cardiac fibrosis PMID: 15983244
19. IP receptors play an important role in preimplantation embryo development and mediate the embryo's response to exogenous PGI(2) PMID: 17905746
20. ONO-54918-07 mimics the effect of PGE1(prostaglandin E1), supporting the notion that the PGE1 effect on NG108-15 cells is mediated by prostacyclin receptors. PMID: 17952410
21. prostacyclin receptor knockout mice showed normal pain behavior in all tests PMID: 18938093
22. PGIS/ IP transgenic animals with lung-specific PPARgamma overexpression also developed fewer lung tumors. PMID: 19138979

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KEGG: mmu:19222

STRING: 10090.ENSMUSP00000122080

UniGene: Mm.287572