Recombinant Mouse Tumor necrosis factor ligand superfamily member 9 (Tnfsf9)

1. this study shows that intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung PMID: 28051085
2. 4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues PMID: 25404362
3. These results demonstrate that 4-1BBL-engineered DCs can improve CIKs cytotoxicity against prostate cancer cells. PMID: 25572476
4. Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions. PMID: 24091276
5. CD137-expressing CD4+ T cells in the bone marrow engage CD137L on hematopoietic progenitor cells, and this CD137L signaling biases hematopoiesis towards myelopoiesis during aging. PMID: 23945137
6. Results suggest that CD137L reverse signaling exerts a pro-apoptotic effect by suppressing integrin-mediated survival signals in neural stem cells. PMID: 23925549
7. A VCAM-1-positive stromal cell is a plausible candidate for the radioresistant cell that provides 4-1BB ligand to sustain memory CD8-positive T cells. PMID: 22886791
8. The CD137L induces tyrosine phosphorylation as well as the up-regulation of M-CSF, IL-1beta and TN-C expressions by knockdown of TMEM126A. PMID: 22885069
9. 4-1BB signaling negatively modulate Treg cells by two distinct mechanisms: i) inhibiting the conversion of CD4(+)FoxP3(-) T cells into iTreg cells and ii) endowing Teff cells refractory to inhibition by Treg cells. PMID: 22870329
10. The CD137L reverse signaling pathway in epithelial cells may represent a good target for blocking the initial stage of inflammatory diseases, including renal ischemia-reperfusion injury. PMID: 22160719
11. Reverse signals initiated by CD137L negatively modulate certain immune functions of thioglycollate-elicited peritoneal macrophages PMID: 21184130
12. Mice inoculated with H22 tumor cells expressing B7-1, B7-2 and 4-1BBL developed a strong cytotoxic T lymphocyte response and long-term immunity against wild-type tumor, suggesting a synergistic effect between the B7 and 4-1BBL costimulatory pathways PMID: 20563597
13. Cocultures of Natural killer (NK) cells with CD137L transfectants confirmed that human CD137 inhibits NK-cell reactivity, while activating signals were transduced by its counterpart on NK cells in mice. PMID: 20008791
14. A role for 4-1BB ligand in dendritic cell activation PMID: 11867564
15. In a murine model, herpetic stromal keratitis is inhibited by blockade of 4-1BBL/4-1BB interactions with monoclonal antibodies to 4-1BBL or by deletion of 4-1BB. PMID: 12847221
16. involvement of 4-1BB in CD4(+) Th1 cell responses by regulating the clonal expansion and survival of CD4(+) T cells as seen in CD8(+) T cells PMID: 14749528
17. Characterization of the role of 4-1BBL in activation and recall response of CD4 T cells vs CD8 T cells. PMID: 14991604
18. demonstrate that suppression of experimental autoimmune uveoretinitis results from antigen-driven, 4-1BB-mediated expansion of novel CD11c+CD8+ T cells that suppress antigen-specific CD4+ T cells via an indole 2,3-dioxygenase-dependent mechanism PMID: 16899371
19. indicate that the CD28 costimulatory pathway plays a major role in the alloimmune response and that 4-1BB signals are dependent upon CD28 signals PMID: 17202836
20. IL-13 was coinduced following 4-1BB triggering to maintain the Th1/2 balance of immune response. PMID: 17389581
21. Thus, long-term inhibition of the 4-1BB pathway reduces cardiac damage, remodeling, and inflammation during viral myocarditis. PMID: 17468777
22. CD137 ligand plays a role in allergic asthma. PMID: 17845419
23. CD80 and 4-1BBL induce auto- and transcostimulation in tumor cells PMID: 18026115
24. deliver new insights into the multiple effects of reverse signaling of CD137L in human DC during the initiation of an adaptive immune response PMID: 18395851
25. IL12- and CD137L-transfected plasmocytoma cells prevented tumor growth and induced long-lasting immunity PMID: 18610746
26. Reverse CD137 ligand signaling takes place in hematopoietic progenitor cells, where it induces proliferation and differentiation toward monocytes and macrophages. PMID: 18768847
27. modification of cancer cells with 4-1BBL gene can produce anti-tumor immune responses. PMID: 18954562
28. During mild respiratory influenza infection in which virus is rapidly cleared, costimulatory receptor 4-1BB is transiently induced on lung T cells and 4-1BB ligand (4-1BBL) is completely dispensable for the initial CD8 T cell response and mouse survival. PMID: 19124736
29. 41BBL requires hexamerization for activation PMID: 19596991
30. CD137L ordinarily regulates the GC B-cell response and thereby acts as a tumor suppressor. PMID: 19608748
31. These findings demonstrate that reverse signals evoked by CD137L regulate immune functions in macrophages. PMID: 19676073
32. 4-1BB ligand induces cell division, sustains survival, and enhances effector functions of CD4 and CD8 T cells under comparable conditions of antigenic stimulation. PMID: 11466348

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KEGG: mmu:21950

STRING: 10090.ENSMUSP00000040412

UniGene: Mm.41171