Name: Recombinant Mouse Voltage-gated hydrogen channel 1(Hvcn1)-VLPs
Brand: CUSABIO
SKU: CSB-MP661026MO

Product Details

Target Names	Hvcn1
Uniprot No.	Q3U2S8
Research Area	Immunology
Alternative Names	Hvcn1; Bts; Vsop; Voltage-gated hydrogen channel 1; Hydrogen voltage-gated channel 1; HV1; Voltage sensor domain-only protein; mVSOP
Species	Mus musculus (Mouse)
Source	Mammalian cell
Expression Region	1-269aa
Target Protein Sequence	MTSHDPKAVTRRTKVAPTKRMSRFLKHFTVVGDDYHTWNVNYKKWENEEEEEEPAPTSAEGEGNAEGPDAEAGSASTPRQSLDFRSRLRKLFSSHRFQVIIICLVVLDALLVLAELLLDLKIIEPDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRLEFFHHKFEILDAFVVVVSFVLDLVLLFKSHHFEALGLLILLRLWRVARIINGIIISVKTRSERQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Tag Info	C-terminal 10xHis-tagged If you have specified tag type, please tell us and we will check if it’s possible to develop.
Form	Lyophilized powder Note: We will default ship it in lyophilized form with normal bule ice packs. However, if you request to ship in liquid form, it needs to be shipped with dry ice, please communicate with us in advance and extra fees for dry ice and dry ice box will be charged.
Buffer	Lyophilized from PBS, 6% Trehalose, pH 7.4
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time. Note: Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes	Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
Datasheet & COA	Please contact us to get it.

Target Background

Function	Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
Gene References into Functions	loss of Hv1 significantly attenuates STZ-induced beta-cell damage and ROS production in pancreatic beta-cells; results suggest that Hv1 might contribute to development of diabetes through producing ROS. PMID: 29550486 Hv1 channels therefore differentially regulate the pHp in neutrophils and macrophages, sustaining rapid acidification in macrophage phagosomes and maintaining a neutral pH in neutrophil phagosomes. PMID: 24415791 microglial Hv1 proton channel is a unique target for modulation of microglial M1/M2 polarization in the pathogenesis of ischemic stroke PMID: 27470181 Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1. PMID: 25885273 The voltage-gated proton channel Hv1/VSOP inhibits neutrophil granule release PMID: 25990245 Our data demonstrated that the expression of Hv1 in pancreatic islet beta-cells regulates insulin secretion through regulating Ca(2+) homeostasis. PMID: 26559003 Eosinophils require proton channel HVCN1 for optimal reactive oxygen species generation and prevention of activation-induced cell death. PMID: 23705768 Data suggest that the biochemical properties of the cytoplasmic coiled-coil domain in the Hv channel depend on the redox condition, which may play a role in redox sensing in the phagosome. PMID: 23667254 Functional expression of voltage-gated proton (Hv1) channels is characterized, for the first time, in mouse bone marrow-derived dendritic cells. PMID: 22572846 inhibition of Hv1 function via knockdown of Hv1 expression can effectively retard cancer growth PMID: 22367212 Hv1 channels maintain a physiological membrane potential during the respiratory burst of neutrophils by providing a compensating charge for the electrons transferred by NOX2 from NADPH to superoxide. PMID: 22056415 Review of structural organization and gating of Hv1 channels discusses relationship between gating of Hvcn1 and the gating of ion-conducting pores recently discovered in the voltage-sensing domains of mutant voltage-gated potassium and sodium channels. PMID: 19915215 HVCN1 -deficieent B cells show a defct in ROS production, which causes less signal transduction through impaired BCR-dependent oxidation of SHP-1. PMID: 20139987 Hv1 channels truncated just downstream of R2 in the S4 segment retain most channel properties. PMID: 20018719 VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification. PMID: 20026664 reported that VSOP, a four-transmembrane protein similar to the voltage-sensor domain of voltage-gated ion channels is a voltage-gated proton channel [VSOP] PMID: 16556803 VSOP/Hv1 is present in phagosome and plays role in production of reactive oxygen species. PMID: 19285483 Hv1 expression is required for measurable voltage-gated H(+) current in unstimulated phagocytes. PMID: 19372380 Show More Hide All
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Protein Families	Hydrogen channel family
Tissue Specificity	Enriched in immune tissues, such as bone marrow, macrophages and spleen.
Database Links	KEGG: mmu:74096 STRING: 10090.ENSMUSP00000072401 UniGene: Mm.28804

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Recombinant Mouse Voltage-gated hydrogen channel 1(Hvcn1)-VLPs

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Code	CSB-MP661026MO
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