Recombinant Mouse Voltage-gated hydrogen channel 1(Hvcn1)

Code CSB-CF661026MO
Product Type Transmembrane Protein
Size US$1668
Uniprot No. Q3U2S8
Relevance Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF661026MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Hvcn1.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-CF661026MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Hvcn1.
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Mus musculus (Mouse)
Purity Greater than 85% as determined by SDS-PAGE.
Sequence MTSHDPKAVTRRTKVAPTKRMSRFLKHFTVVGDDYHTWNVNYKKWENEEEEEEPAPTSAEGEGNAEGPDAEAGSASTPRQSLDFRSRLRKLFSSHRFQVIIICLVVLDALLVLAELLLDLKIIEPDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRLEFFHHKFEILDAFVVVVSFVLDLVLLFKSHHFEALGLLILLRLWRVARIINGIIISVKTRSERQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN
Research Area Immunology
Source in vitro E.coli expression system
Gene Names Hvcn1
Protein Names Hydrogen voltage-gated channel 1 Short name: HV1 Voltage sensor domain-only protein Short name: mVSOP Bts, Vsop
Expression Region 1-269aa
Tag Info N-terminal 10xHis-tagged
Mol. Weight 36.7 kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
Subcellular Location Membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein
Protein Families Hydrogen channel family
Tissue Specificity Enriched in immune tissues, such as bone marrow, macrophages and spleen.
Database Links

KEGG: mmu:74096

STRING: 10090.ENSMUSP00000072401

UniGene: Mm.28804

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