Recombinant Rat Carcinoembryonic antigen-related cell adhesion molecule 1(Ceacam1)

Code CSB-CF005157RA
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names Ceacam1
Uniprot No. P16573
Alternative Names Ceacam1; Carcinoembryonic antigen-related cell adhesion molecule 1; ATP-dependent taurocolate-carrier protein; Cell-CAM 105; C-CAM 105; Ecto-ATPase; GP110; pp120; CD antigen CD66a
Species Rattus norvegicus (Rat)
Expression Region 35-519
Target Protein Sequence QVTVDAVPPNVVEESSVLLLTHNLPQEFQVFYWYKVTTTGLNSEIARYIRSSNTSQTEPAYSGRVTIYSNGSLFFQNVNKTDEGPYTLSVIDKQFNPIQTSVQFRVYPALQKPNVTGNNSNPMEGEPFVSLMCEPYTNNTSYLWSRNGESLSEGDRVTFSEGNRTLTLLNVRRTDKGYYECEARNPATFNRSDPFNLDVIYGPDAPVISPPDIYLHQGSNLNLSCHADSNPPAQYFWLINEKLQTSSQELFISNITTNNSGTYACFVNNTVTGLSRTTVKNITVFEPVTQPSIQITNTTVKELGSVTLTCFSKDTGVSVRWLFNSQSLQLTDRMTLSQDNSTLRIDPIKREDAGDYQCEISNPVSFRISHPIKLDVIPDPTQGNSGLSEGAIAGIVIGSVAGVALIAALAYFLYSRKTGGGSDHRDLTEHKPSTSSHNLGPSDDSPNKVDDVSYSVLNFNAQQSKRPTSASSSPTETVYSVVKKK
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Isoform 1
Gene References into Functions
  1. CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses PMID: 24743304
  2. the transmembrane domain is an important determinant of CEACAM1-4S functionality PMID: 22235309
  3. ovariectomy decreases the mineralization process and the osteocalcin expression during the chronology of the alveolar healing process that is not totally recovered with estrogen replacement or raloxifene treatment. PMID: 20036346
  4. Two novel splice variants, designated CEACAM1-4C1 and CEACAM1-4C2, lacking the transmembrane region, were identified in this study. PMID: 11922629
  5. Both long and short cytoplasmic domain isoforms of Ceacam1 are expressed in rat neutrophils, B cells, and T-cells. PMID: 11994468
  6. the transmembrane domain of CEACAM1 is responsible for the Cdc42-induced targeting at cell-cell contacts PMID: 14517298
  7. the N-domain of CEACAM1 shows evidence of recombination PMID: 15184366
  8. CEACAM1 influences the resolution of inflammation by prolonging the survival of rat granulocytes. PMID: 15909305
  9. CEACAM1 mediates contact inhibition of proliferation in cells that are constantly exposed to growth factors, but co-activates growth-factor-induced proliferation in cells that have been starved for growth factors. PMID: 15950623
  10. PDIP38 can shuttle between the cytoplasmic and the nuclear compartments and that its subcellular localization is regulated by CEACAM1 PMID: 17623671
  11. CEACAM1 is a direct target of SOX9 in the colon epithelium PMID: 18794798
  12. A mechanism involving adhesion-influenced dynamic changes of CEACAM1 microcluster organization exists in epithelial cells. PMID: 19948502
  13. Transmembrane signaling by CEACAM1 operates by alteration of the monomer/dimer equilibrium, which leads to changes in the SHP-2 phosphatase/c-Src kinase-binding ratio. PMID: 19948503

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Subcellular Location Isoform 1: Cell membrane, Single-pass type I membrane protein, Lateral cell membrane, Apical cell membrane, Basal cell membrane, Cell junction, Cell junction, adherens junction, Note=Canalicular domain of hepatocyte plasma membranes (PubMed:8513803), Found as a mixture of monomer, dimer and oligomer in the plasma membrane, Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (PubMed:19948503), Found as dimer in the solution (PubMed:9003371), Predominantly localized to the lateral cell membranes (PubMed:7774714), SUBCELLULAR LOCATION: Isoform 2: Cell membrane, Single-pass type I membrane protein, Lateral cell membrane, Apical cell membrane, Basal cell membrane, Cell junction, Cell junction, adherens junction, Cytoplasmic vesicle, secretory vesicle, Note=Predominantly localized to the lateral cell membranes (PubMed:7774714), Found as a mixture of monomer, dimer and oligomer in the plasma membrane, Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (PubMed:19948503), Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (By similarity), SUBCELLULAR LOCATION: Cell projection, microvillus membrane, Single-pass type I membrane protein, Apical cell membrane, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily, CEA family
Tissue Specificity Expressed in epithelia, vessel endothelia, leukocytes and platelets. Isoform 1 and isoform 2 are highly expressed in liver and intestine, moderately in lung, and weakly in muscle, kidney, and spleen (PubMed:8454589). Expressed in granulocytes, lymphocytes
Database Links

KEGG: rno:81613

STRING: 10116.ENSRNOP00000046654

UniGene: Rn.91235

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