Recombinant Human Tumor necrosis factor receptor superfamily member 12A protein(TNFRSF12A) (Active)

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Code CSB-AP001931HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
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Uniprot No. Q9NP84
Lead Time 5-10 business days
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, TweakR, CD antigen CD266
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inhibiting TWEAK- dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30 ng/ml, corresponding to a specific activity of >3.3x104 IU/mg, in the presence of 15 ng/ml of rHuTWEAK.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Cancer
Source E.coli
Gene Names TNFRSF12A
Expression Region 28-80aa
Tag Info Tag-Free
Mol. Weight 5.6 kDa
Protein Description Partial
PubMed ID 10751351; 15489334; 11728344; 19241374
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Function Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
Database Links

HGNC: 18152

OMIM: 605914

KEGG: hsa:51330

STRING: 9606.ENSP00000326737

UniGene: Hs.355899

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