Code | CSB-RA441307A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
TNFRSF12A, also known as FN14, is a type I membrane protein from the TNFR superfamily and is the receptor for TNFSF12. TNFSF12-TNFRSF12A axis participates in the regulation of multiple cellular processes, including proliferation, migration, differentiation, apoptosis, endothelial dysfunction, inflammation, angiogenesis, tissue remodeling, and thrombosis. TNFRSF12A expression is upregulated in various malignancies, including lung cancer, glioblastoma, and breast cancer. The activation of the TNFSF12-TNFRSF12A signaling pathway also elicits pro-inflammatory responses in many autoimmune and inflammatory diseases.
Compared with the polyclonal and monoclonal antibodies of TNFRSF12A, this TNFRSF12A recombinant antibody has the features of increased reproducibility and control, animal-free technology, high degree of monovalency, high batch-to-batch consistency, easier isotype conversion, etc. And it has been validated in ELISA, WB, IHC.There are currently no reviews for this product.