CD38 (Isatuximab-IRFC Biosimilar) Recombinant Monoclonal Antibody

1. CD38 and cADPR are key players in the orches- tration of cellular responses to respiratory syncytial virus by infected monocyte-derived dendritic cells. PMID: 29178427
2. our data are consistent with the conclusion that CD38 plays a role in murine and human lung tumorigenesis PMID: 29228209
3. isatuximab decreases multiple myeloma cell- and bone marrow stromal cell-induced iTreg by inhibiting both cell-cell contact and TGFbeta/IL10. Finally, CD38 levels correlate with differential inhibition by isatuximab of Tregs from multiple myeloma versus normal donors.Targeting CD38 by isatuximab can preferentially block immunosuppressive Tregs and thereby restore immune effector function against multiple myeloma PMID: 28249894
4. Empathic response mediates the CD38-altruism association. PMID: 28865941
5. Increased levels of HLADR and CD38 expressions in peripheral blood were associated with oral lesions in HIV-positive patients. Periodontal disease was associated with HLADR expression. PMID: 28500735
6. Panobinostat increased CD38 expression in a dose-dependent manner in primary myeloma cells. This was specific for myeloma cells and did not occur in lymphoma cell lines. This increase enabled the antimyeloma activity of daratumumab. PMID: 28476749
7. To demonstrate the therapeutic effect of daratumumab in CLL, we generated a disseminated CLL mouse model with the CD38(+) MEC2 cell line and CLL patient-derived xenografts (CLL-PDX). Daratumumab significantly prolonged overall survival of MEC2 mice, completely eliminated cells from the infiltrated organs, and significantly reduced disease burden in the spleen of CLL-PDX PMID: 27637890
8. CD38 mRNA levels were correlated with lower Autism Quotient (AQ), indicating enhanced social skills. CD38 expression and CD157 eQTL SNPs altogether account for a substantial 14% of the variance in sociality. the ecological validity of these findings was demonstrated with subjects with higher PBL CD38 expression having more friends, especially for males. PMID: 28212520
9. CD38(lo) luminal cells are enriched in glands adjacent to inflammatory cells and exhibit epithelial nuclear factor kappaB (NF-kappaB) signaling. In response to oncogenic transformation, CD38(lo) luminal cells can initiate human prostate cancer in an in vivo tissue-regeneration assay PMID: 27926864
10. Results provide evidence that CD38 enhanced the proliferation and inhibited the apoptosis of cervical cancer cells by affecting the mitochondria functions. PMID: 28544069
11. these data demonstrate an important role for CD38 and complement-inhibitory protein expression levels in daratumumab sensitivity. PMID: 27307294
12. Results may imply that CD38 expression either reflects or participates in pathogenic mechanisms of HIV disease independently of cell cycling. PMID: 27064238
13. The data suggest that ZO-1, along with CD38 and Zap-70, plays a role in cell cycle regulation in chronic B cell leukemia, and may be used as a prognostic marker in the disease monitoring. PMID: 26306999
14. Primary human melanoma cell lines suppress in vitro T cell proliferation through an adenosinergic pathway in which CD38 and CD73 play a prominent role. PMID: 26329660
15. CD38 and its related genes are highly expressed in human nasopharyngeal carcinoma cell lines. PMID: 25630761
16. soluble CD38 (sCD38) in seminal plasma increases the capacitation of sperm via specific interactions between sCD38 and the CD31 on the sperm. PMID: 26407101
17. the expression of CD38+ on both CD4+, CD8+T lymphocytes from peripheral blood and CSF discriminated between viremic and non-viremic patients PMID: 26365593
18. study points to an association between maternal SNPs in the CD38 in Japanese women and susceptibility to preterm birth. PMID: 26025338
19. Peripheral blood CD38 bright CD8+ effector memory T cells predict acute graft-versus-host disease. PMID: 25881755
20. CD38 is expressed on human MDSC-like cell population that is expanded in the peripheral blood of advanced-stage cancer patients. PMID: 26294209
21. Upregulation of CD38 expression on multiple myeloma cells by all-trans retinoic acid improves the efficacy of daratumumab. PMID: 25975191
22. Genetic variation in CD38 and breastfeeding experience interact to impact infants' attention to social eye cues. PMID: 26371313
23. genetic polymorphism is associated with diffuse large B-cell lymphoma susceptibility in Egyptians PMID: 25564959
24. Hairy-cell leukemia patients that were CD38-positive had a shorter mean time to salvage therapy than CD38-negative ones. CD38 expression in HCL drives poor prognosis by promoting survival and heterotypic adhesion. PMID: 26170397
25. alterations in content of soluble molecules CD38 are associated with characteristics of tumor process that indicates at their monitoring significance under malignant neoplasms of uterus PMID: 26470437
26. The results indicate that the net charge of the N-terminal segment is important in determining the membrane topology of CD38 and that the type III orientation can be a functional form of CD38 for Ca(2)-signaling. PMID: 25447548
27. The majority of extranodal NK/T cell lymphoma cases were CD38 positive, which significantly correlated with poor outcomes. PMID: 25865943
28. High levels of CD38 reduced intracellular (NAD+) levels and blocked acquired resistance by inhibiting the activity of the NAD+-dependent SIRT1 deacetylase PMID: 24967705
29. CD38 status was associated with behavior and psychological reactions within live interactions, as well as global relationship quality PMID: 24396004
30. These results validate CD38 as a therapeutic target and support the current evaluation of this unique CD38-targeting functional antibody in phase I clinical trials in patients with CD38+ B-cell malignancies. PMID: 24987056
31. At the same time, CD38 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo PMID: 25310288
32. CD38 expression is regulated by micro-RNA 708 in airway smooth muscle cells. PMID: 25175907
33. CD38 has a role in chronic lymphocytic leukemia growth and trafficking PMID: 24990614
34. Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-gamma by a T-bet-dependent mechanism. PMID: 25505279
35. Increased numbers of circulating ICOS(+) and IL-21(+) Tfh and CD38(+) plasma cells may be exhibited by patients with recent diagnoses of primary biliary cirrhosis. PMID: 25404409
36. nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38 PMID: 24635660
37. Autism and features of regression-previously acquired speech lost in the second year of life. The younger sister, who also had asthma, inherited a maternal deletion of 4p15.32 that results in a BST1-CD38 fusion transcript. PMID: 24634087
38. results demonstrate that CD38(+) cells are a useful model to study effects of the cellular NAD levels on cellular processes and establish a new linker between cellular NAD levels and oxidative stress PMID: 24295520
39. only one SNP in CD38 was significantly associated with social integration and that SNP predicted when using a dichotomized indicator of social connectedness, but not a continuous measure of social connectedness or the continuously married outcome. PMID: 24209975
40. Data suggest that the uniquely increased expression of CD38 and E2F2 in rheumatoid arthritis (RA) synovial tissues contribute to the immunoactivation of the disease. PMID: 24397353
41. PBMC from MM patients display a deregulated response related to CD38 activation pathway defects; CD38 may be functionally involved in the progression of this pathology via the secretion of high levels of IL-6 that protects neoplastic cells from apoptosis PMID: 24489445
42. These data suggest that both functional roles of CD38 might be important in the pathogenesis of B-CLL. PMID: 24216102
43. Atorvastatin and rosiglitazone did not affect the expression of CD38. PMID: 23686733
44. Data suggest CD38 (CD38 antigen (p45) protein) and CD49d (alpha4 Integrin; very late antigen-4 alpha) are more than just markers of an aggressive chronic lymphocytic leukemia (CLL) cell type and play functional roles in pathobiology of CLL. [REVIEW] PMID: 24288111
45. CD38 is expressed within caveolae and its function is linked to the caveolar regulatory proteins. PMID: 24275509
46. Report diagnosis of multiple myeloma using two-color flow cytometry based on kappa/lambda ratios of CD38-gated plasma cells. PMID: 23755763
47. CD38-cADPR mediates bile acid-induced pancreatitis and acinar cell injury through aberrant intracellular Ca(2+) signaling. PMID: 23940051
48. The frequency of CD38high antibody-secreting cells (ASCs) is increased during the acute phase of hepatitis A virus (HAV) infection. Substantial numbers of ASCs are non-HAV-specific and dominantly secrete IgM. PMID: 23729443
49. Data show that ADP-ribosylation of CtBP1-S/BARS by brefeldin A (BFA) occurs via synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. PMID: 23716697
50. CD38 signals upregulate expression and functions of matrix metalloproteinase-9 in chronic lymphocytic leukemia cells. PMID: 22955446

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HGNC: 1667

OMIM: 107270

KEGG: hsa:952

STRING: 9606.ENSP00000226279

UniGene: Hs.479214