CUSABIO Monthly Citation Review: 240 New Product Citations in August, Total Citations Hit 27,200!

A 76-year-old heavy smoker presented with progressive proximal weakness and respiratory failure; electrophysiology and anti-SOX1 antibodies confirmed Lambert–Eaton myasthenic syndrome, PET-CT revealed small-cell lung cancer, and combined oncologic and symptomatic therapy led to partial recovery, highlighting the need to screen for paraneoplastic neurologic syndromes.

Integrated WGS/RNA-seq of 203 ESCCs shows MUC mutations and APOBEC signatures predict poor outcome, whereas EpK pathway activation and high S100A8/A9 indicate favorable prognosis. A FU-ESCC three-subtype classifier stratifies patients—EpK, CAF-enriched, and immune-desert—guiding precision therapy.

This study reveals that the mast cell receptor Mrgprb2, and its human ortholog MRGPRX2, orchestrate post-stroke brain inflammation by recruiting skull bone marrow neutrophils via the dura-brain axis, and inhibiting this receptor alleviates inflammation and improves outcomes.

Using whole-cell phage display, we identified CD30L-targeting peptide TG-1 that disrupts CD30-CD30L signaling to suppress B-NHL proliferation; TG-1-conjugated gold nanoparticles co-delivering doxorubicin demonstrated potent and precise antitumor effects in vitro and in vivo.

The study reveals diabetic wounds lack Galectin-3 due to AGE interference; topical Gal-3 rescues healing by forming LLPS with integrin α5β1 to activate FAK-driven angiogenesis without systemic insulin resistance. Hydrogel delivery or combination with insulin further accelerates closure.

An MD-guided active-learning framework identified BMS-262084 as a nanomolar TMPRSS2 inhibitor with <20 experimental tests, potently blocking entry of SARS-CoV-2 variants and diverse coronaviruses.

Three-month swimming in 1–4-month-old C57BL/6J mice, followed by lifelong detraining, did not extend overall lifespan but markedly improved healthspan in both sexes by enhancing metabolism, cardiovascular and musculoskeletal function, reducing inflammation and frailty; skeletal muscle fatty-acid oxidation was identified as the key molecular signature.

Core-shell nanoparticles sequentially release ASNase and rotenone to exhaust extracellular and intracellular asparagine, strongly suppressing growth, relapse and metastasis of TNBC and CRC while inducing durable T-cell memory, offering a general amino-acid-depletion strategy for solid tumors.

ACSS2 epigenetically upregulates hepcidin HAMP1/2 via CBP-mediated histone acetylation, restraining iron overload and hepatocyte ferroptosis in ALD. Hepatocyte-specific ACSS2 deletion worsens alcohol-induced liver injury, whereas ACSS2 overexpression or ferroptosis/hepcidin supplementation rescues pathology, identifying ACSS2 as a promising therapeutic target.

Intestinal α-lipoic acid (ALA) declines with aging; supplementing ALA reverses human and murine ISC aging and boosts epithelial renewal. ALA suppresses mTOR signaling in Paneth cells, elevating cADPR and lowering Notum secretion to enhance ISC function and reduce abnormal Paneth-cell accumulation, offering a therapeutic avenue for age-related intestinal diseases.