Mouse Interleukin 6,IL-6 ELISA KIT

1. These results suggest that TCF21 contributes to the proinflammatory environment in VIS fat depots and to active ECM remodeling of these depots by regulating IL6 expression and MMP-dependent ECM remodeling in a spatiotemporally coordinated manner. PMID: 29540474
2. Notch signaling regulates cell density-dependent apoptosis through IL-6/STAT3-dependent mechanism. PMID: 30249464
3. Obesity-induced IL-6 shifts macrophage polarization towards tumor-promoting macrophages that produce the CCL-20 in the colitis-associated colorectal cancer (CAC) microenvironment. CCL-20 promotes CAC progression by recruiting CCR6-expressing B-cells and gammadelta T cells via chemotaxis. PMID: 29695802
4. In glioblastoma, colony-stimulating factor-1 and angiocrine IL-6 induce robust arginase-1 expression and macrophage alternative activation, mediated through peroxisome proliferator-activated receptor-gamma-dependent transcriptional activation of hypoxia-inducible factor-2alpha. PMID: 29422647
5. microbiota provide a homeostatic role for epithelial barrier function through regulation of intraepithelial lymphocytes -derived IL-6 PMID: 28812548
6. Ischemia augments alloimmune injury through IL-6-driven CD4+ alloreactivity. PMID: 29410442
7. Results suggest that IL-6 contributes to limit lipid metabolic disorder, cardiac hypertrophy, fibrosis, inflammation and myocardium lipotoxicity during HFD-induced obesity. PMID: 28844956
8. CD37 may protect against IgA nephropathy by inhibition of the IL-6 pathway. PMID: 29551516
9. IL-6/Stat3 signaling drives a transcriptional program of antimicrobial gene expression in infected urothelium, with key roles in limiting epithelial invasion and ascending infection. PMID: 29475562
10. IL-6 and STAT3 have roles in potentiating FGF19-driven hepatocellular carcinoma (HCC) in mice; this finding may have translational relevance in HCC pathogenesis PMID: 28508871
11. IGF-1R signalling contributes to T cell dependent inflammation in arthritis. Inhibition of IGF-1R on the level of insulin receptor substrates alleviates arthritis by restricting IL6-dependent formation of Th17 cells and may open for new treatment strategies in rheumatoid arthritis. PMID: 28583713
12. The present study demonstrates for the first time that IL-6 trans-signaling is involved in the pathomechanisms of compromised fracture healing after severe injury, whereas IL-6 classic signaling rather mediates pro-regenerative effects augmenting bone regeneration PMID: 29497762
13. persistent stimulation with titanium particles may lead to a consistent release of TNF-alpha and IL-6 via SPHK-2 activity, which may lead to aseptic implant loosening PMID: 29728804
14. IL-6-STAT3 signaling facilitates TRIM28 binding to the Il17-Il17f locus, and this process is required for epigenetic activation and high-order chromosomal interaction in autoimmune experimental encephalomyelitis. PMID: 29651155
15. IL-6 induces utrophin expression through NRG-1/ErbB pathway in dystrophic myotubes. PMID: 27988307
16. IL-6 overexpression could enhance cardiomyocyte proliferation and relevant protein expression in mice myocardium, thus promoting cardiac regeneration. PMID: 29966974
17. data revealed that IL-6 regulates the excessive release of NO through IL-1beta inhibition and determines the establishment of an M2 macrophage profile within infected heart tissue. PMID: 28087471
18. IL-6 plays a role in consolidation process. PMID: 29619678
19. IL-6 expands dendritic cell and monocytic populations and ultimately leads to a robust T-cell driven immune response in Complete Freund's Adjuvant immunized mice. PMID: 28474508
20. These results suggested that the thrombinstimulated synthesis of IL6 was limited by HSP90 in osteoblasts, and that the effects of HSP90 were exerted at the point between Rhokinase and p38 MAPK. PMID: 30066835
21. Results suggest that interleukin 6 (IL-6) may be exploited for lung repair during influenza infection. PMID: 28262742
22. YY1 was progressively up-regulated in BV2 microglial cells stimulated with lipopolysaccharide (LPS), which was dependent on the transactivation function of nuclear factor kappa B (NF-kappaB). Furthermore, YY1 knockdown notably inhibited LPS-induced the activation of NF-kappaB signaling and interleukin-6 (IL-6) expression in BV-2cells. PMID: 29803672
23. The authors conclude that Mycobacterium tuberculosis ESAT-6 stimulates macrophage IL-6 production through STAT3 activation. PMID: 28106119
24. IL-6/soluble IL-6R differentially regulate RANKL-induced osteoclast differentiation and activity through modulation of NF-kappaB, ERK and JNK signaling pathways. PMID: 28128332
25. These results suggest that the inhibition of IL6/STAT3 signaling is a potential mechanism by which PZH is used in the treatment of ulcerative colitis. PMID: 29845215
26. CXCL9 may promote prostate cancer progression via inhibition of cytokines from T cells. PMID: 29901197
27. results suggest that IL-6 gene requires up-regulation of phospho-JAK2/STAT3, PACAP, and PAC1R and down-regulation of the TNF-alpha gene to modulate its anticonvulsive/neuroprotective potential PMID: 29673861
28. Toll-like receptor 4 (TLR4) requires physical and functional association with Fcalpha-mu protein (Fcalpha/muR) for its oligomer formation and interleukin-6 (IL-6) production from marginal zone (MZ) B cells. PMID: 27146354
29. TRYP improves the health condition of mice with DSS induced colitis by regulating the TNF-α/NF-κBp65 and IL-6/STAT3 signaling pathways via inhibiting the degradation of IκBα and the phosphorylation of STAT3. PMID: 29724065
30. Our results demonstrate that IL-6 activation in placenta is required for relaying inflammatory signals to the fetal brain and impacting behaviors and neuropathologies relevant to neurodevelopmental disease. PMID: 27838335
31. An IL-6 infusion model can initiate macrophage accumulation as well as aortic dilation, and under conditions of elevated tension, this proinflammatory cytokine can be produced by aortic vascular smooth muscle cells. PMID: 29107003
32. miR-155 seems to target Est-1 and induces ulcerative colitis via the IL-23/17/6-mediated Th17 pathway. PMID: 28888763
33. IL-6 and aging are involved in regulation of PPARalpha and PGC-1alpha expression and may influence the mitochondrial function. PMID: 29173012
34. CGRPinduced IL6 mRNA expression was mediated by mmu_circRNA_007893. PMID: 29039515
35. The results of this study indicated that persistently increased levels of IL-6 can lead to alterations in mTOR regulation of L-LTP. PMID: 29104031
36. These data demonstrate that the Pb18 strain of Paracoccidioides brasiliensis is able to activate the transcription of Notch1 receptor in J774 macrophages. Activation of this receptor with also activation of TLR 4 (via LPS) induces IL-6 production, which favors the pathogenesis. PMID: 28600728
37. IRF-1 may be at the nexus of the interplay between IFN-gamma and IL-6 in exacerbating a xenobiotic-induced inflammatory response, regulation of interferon responsive genes and autoimmunity PMID: 28453771
38. IL 6 and TGF beta perform essential role in cerebral malaria pathogenesis by modulating the level of glial cell induced neuroinflammation. PMID: 28803696
39. These results suggest that glucocorticoids' effects on adipose tissue immune response, both in a pro- and an anti-inflammatory manner, depend on the nutritional status. PMID: 29847081
40. EMMPRIN inhibited bFGF-induced IL-6 secretion by reducing the p65 subunit phosphorylation, it might be concluded that bFGF and EMMPRIN crosstalk in their respective signaling pathways. PMID: 29104472
41. pathologic levels of IL-6 in the periphery may play a role in the development of seizures when viral replication within the brain is limited following infection with a variant of Theiler's murine encephalomyelitis virus that does not replicate within the parenchyma of the brain. PMID: 28741149
42. TIARP independently down-regulated CXCL2 and IL-6 production by fibroblast-like synoviocytes, and the expression of chemokine receptors (CXCR1 and CXCR2) in neutrophils, with resultant reduction of neutrophil migration into arthritic joints. PMID: 27995997
43. these findings revealed a novel and unexpected role of IL-6 in ameliorating acute liver injury via regulating inflammatory responses in hepatic macrophages PMID: 28822324
44. increased circulating levels of IL-6 perturb the redox signaling cascade, even prior to the necrotic stage, leading to severe features and progressive nature of muscular dystrophy. PMID: 28845212
45. LPS increased mRNA and protein expressions of IL-6 and RANKL on day 14 PMID: 28637991
46. role in keratinocyte migration and proliferation through modulation of TGF-betaR expression and function PMID: 27892604
47. The in vitro findings suggest that GTS-21-induced IL-6 release from muscle is mediated via alpha7AChRs upstream of Stat-3 and -5 pathways and is associated with myonuclear accretion, possibly via MyoD and Pax7 expression. PMID: 28282360
48. Burn serum caused muscle cell death associated with increased mitochondrial fission and functional impairment. This alteration was alleviated with IL-6 antibody treatment, suggesting the cytokine plays a role in mitochondrial changes in muscle after systemic injury. PMID: 28181922
49. This study demonstrates that obesity-associated inflammation and metabolic disturbances depend on interleukin-6/Stat3-dependent formation of a distinct natural killer population, which may provide a target for the treatment of obesity, metaflammation-associated pathologies, and diabetes. PMID: 28683285
50. In the CNS, LPS administration had the greatest effect on IL-6 and LPS increased IL-6 mRNA expression only in non-neuronal cells. PMID: 28456715
51. these data show that suggest that hepatic IL-6 production is maintained during endotoxin tolerance and facilitates lipid accumulation PMID: 28132721
52. High IL-6 expression is associated with invasiveness of pancreatic intraepithelial neoplasia and cancer. PMID: 27602757
53. Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-kappaB signaling pathway in mouse skin. PMID: 28330776
54. By comparing wild type (WT) animals with genetically modified (TG) mice in which central IL-6 trans-signaling was blocked, study showed that central IL-6 trans-signaling modulates basal synaptic transmission as well as seizure excitability. Increases in both mEPSC and sEPSC frequency suggests that the presynaptic component of excitatory synapses undergo an enhanced development in TG vs.WT animals. PMID: 28481031
55. Taken together, the results of our present study indicated that DHCE could inhibit cellular proliferation and induce cell apoptosis in myeloma cells mediated through different mechanisms, possibly through inhibiting the IL-6/STAT3 and ERK1/2 pathways. And it may provide a new therapeutic option for MM patients. PMID: 28338993
56. In a double-hit murine model of ARDS, IL-6 deficient mice experienced more severe bronchoalveolar cellular inflammation as compared to wild-type littermates. Furthermore, IL-6 deficiency caused marked acute pulmonary hypertension, which may be, at least partially, due to vasoactive mechanisms. A dysregulation of nitric oxide synthase may account for this observation, a hypothesis that will need to be investigated in futur PMID: 28424078
57. Data (including data from studies using knockout mice) suggest that early initiation of endometriosis is predominantly dependent on immune system; cross-talk occurs between Esr1 and Il6 pathways during early initiation of endometriosis lesion development; estradiol stimulation of Esr1 appears to play minor role in early lesion development. (Esr1 = estrogen receptor alpha; Il6 = interleukin 6) PMID: 28927243
58. Results show that interleukin 6 (IL6) promotes oval cell proliferation and liver regeneration, while tumor necrosis factor alpha (TNFalpha) and TNF receptor-1(TNFR1) do not affect this process. PMID: 27556180
59. IL-6 role in the bone corticalization PMID: 28993616
60. thrombin is increased in a mouse model of cancer cachexia in a partially interleukin-6 dependent manner PMID: 28058802
61. results suggest that the intrinsic microglial clock modulates the inflammatory response, including the positive regulation of IL-6 expression in a particular pathological situation in the brain PMID: 27726182
62. These results show that the systemic IL-6 effector pathway mediates bone deterioration induced by repetitive inhalant ODE exposures through an effect on osteoclasts, but a positive role for IL-6 in the airway was not demonstrated. IL-6 might be an important link in explaining the lung-bone inflammatory axis. PMID: 27875664
63. skeletal muscle IL-6 contributes to reestablishing metabolic homeostasis during recovery from exercise by regulating WAT and skeletal muscle metabolism PMID: 29253016
64. High dilutions of antimony modulate cytokines production and macrophage - Leishmania (L.) amazonensis interaction in vitro. PMID: 28092793
65. pattern of STAT indicates that possibly TGF-beta and IL-6 play a crucial role in differentiation of DCs subsets and Treg/Th17 imbalance during experimental cerebral malaria (ECM). PMID: 27632786
66. IL-6 promotes CD4(+) T-cell activation and B-cell responses during blood-stage Plasmodium infection, which encourages parasite-specific antibody production. PMID: 28748530
67. A2BARs activation increased IL-6 secretion. PMID: 27974241
68. In the context of the elastase model of abdominal aortic aneurysm disease, IL-6 appears a multi-faceted factor, protective upon acute injury, but negatively involved in the perpetuation of the disease process PMID: 27318834
69. Results demonstrate that increased tumor-associated macrophages-derived IL-6 had an amplifying effect on the inflammation response, thereby promoting the occurrence and development of hepatocellular carcinoma (HCC). PMID: 27589954
70. activation of beta2-AR accelerated hepatocyte proliferation and improved recellularized liver function by mediating the IL-6/Stat 3 signalling pathway, indicating that nervous system regulation may be an essential component contributing to the complexity of recellularized liver in tissue engineering PMID: 27811394
71. Taken together, we indicated that anti-IL-6 and anti-TNF-alpha therapy prevent intestinal permeability induced by intestinal inflammation PMID: 27155817
72. However, the mechanism that induces release of IL-6 from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway. PMID: 27979980
73. IL-6 induces prostate oncogenesis through amplifying local inflammation. PMID: 28077171
74. IFN-gamma/TNFalpha activate the JAKs/STAT3 signaling pathway in an IL-6-independent manner in skeletal muscle fibers. PMID: 28264935
75. interactions between TNF-alpha and IL-6 exacerbate oxidative stress and reduce phosphorylation of eNOS, thereby contributing to coronary endothelial dysfunction in T2D mice. PMID: 29095915
76. Data show that lack of B cell-derived IL-6 abrogates spontaneous germinal centers (GCs) formation in systemic lupus erythematosus (SLE). PMID: 28899868
77. miR29c stimulation during influenza virus entry enhances the ability of dendritic cells to activate lymphocytes and secrete cytokines IL-6 or TNF-alpha. PMID: 28063705
78. dual oxidase-2 and IL-6 play important roles in GPR43-mediated skin inflammation. PMID: 28212864
79. HDAC3-deficient chondrocytes exhibited increased expression of cytokine and matrix-degrading genes (Il-6, Mmp3, Mmp13, and Saa3) and a reduced abundance of genes related to extracellular matrix production, bone development, and ossification (Acan, Col2a1, Ihh, and Col10a1). PMID: 27507649
80. Our study is the first to show the important role of IL-6 in regulating cardiac pathogenesis via inflammation and apoptosis during AngII-induced hypertension. We also provide a novel link between IL-6/STAT3 and EndoG/MEF2A pathway that affects cardiac hypertrophy during AngII stimulation. PMID: 29079193
81. It enhances hepatic ketogenesis via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor kappaB p65. PMID: 28528772
82. found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27 PMID: 28953978
83. results suggest that IL-6 plays an important but limited role in AAA pathogenesis, and primarily regulates cell migration and infiltration PMID: 28982132
84. The analysis points to a critical role for Hoxa9 and PU.1 in distal regulation of c-myb expression in murine myeloid cells during iL-6-induced cell differentiation. PMID: 27607579
85. these findings suggested that IL6 gene deficiency antagonized HFD-induced bone loss. PMID: 27493246
86. Long-term exposure to atmospheric particulates, PM2.5 up-regulated H3K4 and H3K9 methylation in IL-6 and IFN-beta promoter regions through down-regulating Kdm6a expression. The results suggest that short-term exposure to PM2.5 significantly enhances the survival rate of influenza A-contaminated mice, while long-term PM2.5 inhalation lowers the capacity of pulmonary macrophages to secrete IL-6 and IFN-beta. PMID: 28887033
87. This study suggests direct stimulation of autophagy as a novel mechanism for IL-6-mediated protection of beta cells from stress-induced apoptosis. PMID: 28592636
88. Internalized CpG oligodeoxynucleotide (ODN)-conjugated PPMs (PPM-CpG) greatly enhance the induction of selected cytokines (TNF-alpha and IL-6) in RAW 264.7 cells compared to that by the soluble CpG ODN and ionic complexes. PMID: 27503807
89. IL-6 is one of the factors produced by the elicited inflammatory response to HSV-1 infection contributing to nerve regression. PMID: 27497323
90. IL-6 likely up-regulates IRP1 and DMT1 expression and down-regulates FPN1 expression in BV2 microglial cells through JNK signaling pathways PMID: 28672025
91. these results suggest that IL-23 plays a critical role in regulation of Th17 cytokines. Furthermore, IL-6 and TGF-beta do not appear to influence IL-23-mediated restoration of Th17 cytokines after ethanol and burn injury. PMID: 28684599
92. This work demonstrates that autocrine IL-6 signaling in the gut epithelium regulates crypt homeostasis through the Paneth cells and the Wnt signaling pathway. PMID: 28550196
93. Early and direct IL-6 signals to memory CD4 T cells are required to program maximal secondary effector responses at the site of infection during heterosubtypic challenge, indicating a novel role for a costimulatory cytokine in recall responses. PMID: 27647834
94. 6 h post injury, IL-6 mRNA expression was significantly lower in diabetic wounds. Abnormal macrophage activation, but not the lower abundance of CD68-expressing macrophages, was found to be characteristic of diabetic wounds. IL-6 played a key role in facilitating non-diabetic fibroblast migration during wound healing via the p38 MAPK-Akt pathway. This signaling pathway was found to be dysfunctional in diabetic fibroblasts PMID: 28542434
95. Social isolation also increased IL-6 levels in the medial prefrontal cortex, and administration of an IL-6 inhibitor (ND50 = 0.01-0.03 mug for 0.25 ng/ml IL-6) ameliorated remyelination impairments PMID: 27613805
96. Adipose-derived stem cells play a pro-malignant role in tumor development of Lewis lung carcinoma cells by particularly promoting cancer stem cell property through interleukin-6 paracrine circuit. PMID: 27596042
97. Absence of IL-6 did not affect overall pathogenesis of Bacillus cereus endophthalmitis. PMID: 27286792
98. SorLA ectodomain, released from the cell membrane upon enzymatic cleavage of full-length SorLA, may act as an IL-6 carrier protein that stabilizes IL-6 and its capacity for trans signaling. PMID: 28265003
99. These findings suggest that downregulation of miR-142-3p in macrophages of aged mice might contribute to IL-6-associated aging disorders and that epigenetic modification might be involved in age-related inflammatory diseases. PMID: 27788393
100. IL-6 can directly induce the transition of HSCs toward myofibroblast-like cells. The effect is mediated by the activation of both MAPK and JAK/STAT signaling pathways. Elimination of either MAPK or JAK/STAT signaling pathways inhibits HSC stimulation PMID: 28472150

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KEGG: mmu:16193

STRING: 10090.ENSMUSP00000026845

UniGene: Mm.1019