AIFM3 Antibody

Datasheet

Code	CSB-PA000835
Size	US$119
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Image	Western Blot analysis of HeLa cells using AIFL Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q96NN9

Target Names

AIFM3

Alternative Names

AIFL antibody; Aifm3 antibody; AIFM3_HUMAN antibody; Apoptosis inducing factor 3 antibody; Apoptosis inducing factor like antibody; Apoptosis inducing factor like protein antibody; Apoptosis inducing factor; mitochondrion associated antibody; Apoptosis-inducing factor 3 antibody; Apoptosis-inducing factor-like protein antibody; FLJ30473 antibody; FLJ45137 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the N-terminal region of Human AIFL.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.

Gene References into Functions

Upregulated expression of AIFM3 is associated with cholangiocarcinoma. PMID: 27473083
The expression of apoptosis-inducing factor was identified in pineal gland and thymus, but it did not change with age. PMID: 22550867
AIFM3 is a direct target of miR-210 in human hepatoma cells. PMID: 22387901
AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). AIFL shares 35% homology with AIF, mainly in the Pyr_redox domain. PMID: 15764604
AIF maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function. PMID: 16001080
H. pylori triggers apoptosis in AGS cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c and AIF from mitochondria, and activation of subsequent downstream apoptotic events PMID: 19166416

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Subcellular Location

Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis.

Protein Families

FAD-dependent oxidoreductase family

Tissue Specificity

Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level).

Database Links

HGNC: 26398

OMIM: 617298

KEGG: hsa:150209

STRING: 9606.ENSP00000382120

UniGene: Hs.723246

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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