AKR7A2 Antibody

Datasheet

Code	CSB-PA001550ESR1HU
Size	US$166
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Image	Western blot All lanes: AKR7A2 antibody at 0.88µg/ml Lane 1: Mouse small intestine tissue Lane 2: Mouse liver tissue Lane 3: Mouse gonadal tissue Lane 4: A431 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 40 kDa Observed band size: 40 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001550ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA001550ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) AKR7A2 Polyclonal antibody

Uniprot No.

O43488

Target Names

AKR7A2

Alternative Names

AFAR antibody; AFAR1 antibody; AFB1 aldehyde reductase 1 antibody; AFB1 AR1 antibody; AFB1-AR 1 antibody; AFB1AR1 antibody; Aflatoxin aldehyde reductase antibody; Aflatoxin B1 aldehyde reductase member 2 antibody; Aflatoxin beta1 aldehyde reductase antibody; Aiar antibody; AKR7 antibody; Akr7a2 antibody; Aldo keto reductase family 7 antibody; Aldo keto reductase family 7 member A2 aflatoxin aldehyde reductase antibody; Aldo keto reductase family 7 member A2 antibody; Aldo keto reductase family 7; member A2 (aflatoxin aldehyde reductase) antibody; Aldoketoreductase 7 antibody; ARK72_HUMAN antibody; SSA reductase antibody; Succinic semialdehyde reductase antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Aflatoxin B1 aldehyde reductase member 2 protein (100-359AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Gene References into Functions

AKR7A2 physically interacts with CYGB. PMID: 28536627
induced expression in human monocytes following exposure to Aflatoxin B1 PMID: 25027672
AKR7A2 contributes to protection against MG-induced toxicity. PMID: 25451587
structure and tissue-related expression of AFAR genes on chromosome 1 PMID: 12879023
The human aldo-keto reductase AKR7A2 has been proposed previously to catalyze the NADPH-dependent reduction of succinic semialdehyde (SSA) to gamma-Hydroxybutyrate in human brain PMID: 17591773
The human AFAR gene family maps to a genomic region in 1p36 of frequent hemizygous deletions in various human cancers. PMID: 18752886
Aflatoxin B(1) aldehyde reductase (AKR7A2) was confirmed to be only highly expressed in pancreatic cancer, not in normal adjacent pancreas and benign tumors. PMID: 19077459

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Subcellular Location

Golgi apparatus. Cytoplasm.

Protein Families

Aldo/keto reductase family, Aldo/keto reductase 2 subfamily

Tissue Specificity

Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels

Database Links

HGNC: 389

OMIM: 603418

KEGG: hsa:8574

STRING: 9606.ENSP00000235835

UniGene: Hs.571886

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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