AMIGO2 Antibody

Datasheet

Code	CSB-PA176639
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA176639(AMIGO2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA176639(AMIGO2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A172 cells, Primary antibody: CSB-PA176639(AMIGO2 Antibody) at dilution 1/597, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

Q86SJ2

Target Names

AMIGO2

Alternative Names

Adhesion molecule with Ig like domain 2 antibody; ALI 1 antibody; ALI1 antibody; Alivin 1 antibody; Alivin-1 antibody; Alivin1 antibody; AMGO2_HUMAN antibody; AMIGO 2 antibody; AMIGO-2 antibody; Amigo2 antibody; Amphoterin induced gene 2 antibody; Amphoterin induced protein 2 antibody; Amphoterin-induced gene and open reading frame 2 antibody; Amphoterin-induced protein 2 antibody; DEGA antibody; Differentially expressed in gastric adenocarcinoma antibody; Differentially expressed in gastric adenocarcinomas antibody; Transmembrane protein AMIGO 2 antibody; Transmembrane protein AMIGO2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human AMIGO2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

Gene References into Functions

Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells. PMID: 28272394
this study uncovers mechanisms underlying the therapeutic effects of BETi in melanoma and reveals the AMIGO2-PTK7 axis as a targetable pathway for metastatic melanoma. PMID: 29149598
AMIGO2 is an important regulator of the PDK1-Akt pathway. PMID: 26553931
Expression of ali1 promotes depolarization-dependent survival of cerebellar granule neurons. Mouse ali1 mapped to a chromosome 15 locus syntenic to candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12. PMID: 12843293
Stable expression of a DEGA/AMIGO-2 antisense construct led to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion/migration, and a nearly complete abrogation of tumorigenicity in nude mice. PMID: 15107827

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Nucleus.

Protein Families

Immunoglobulin superfamily, AMIGO family

Tissue Specificity

Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.

Database Links

HGNC: 24073

OMIM: 615690

KEGG: hsa:347902

STRING: 9606.ENSP00000266581

UniGene: Hs.121520

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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