ANXA8 Antibody

Datasheet

Code	CSB-PA441788
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA441788(ANXA8 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA441788(ANXA8 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: CSB-PA441788(ANXA8 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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Product Details
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Target Background

Product Details

Uniprot No.

P13928

Target Names

ANXA8

Alternative Names

Annexin A8 antibody; Annexin VIII antibody; Annexin-8 antibody; ANX8 antibody; Anxa8 antibody; ANXA8_HUMAN antibody; VAC beta antibody; VAC-beta antibody; Vascular anticoagulant beta antibody; Vascular anticoagulant-beta antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human ANXA8

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:200-1:1000
IHC	1:50-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Gene References into Functions

These findings identify Anxa8 as a regulator of late endosomes/lysosomes cholesterol balance. PMID: 29306076
We conclude that AnxA8 affects CD63/VEGFR2/beta1 integrin complex formation, leading to hyperactivation of the VEGF-A signal transduction pathway, and severely disturbed VEGF-A-driven angiogenic sprouting. PMID: 28060564
Annexins A2 and A8 in endothelial cell exocytosis and the control of vascular homeostasis PMID: 27451994
Increased annexin A8 expression is associated with poor prognosis in early-stage pancreatic cancer. PMID: 25268673
High ANXA8 gene expression is associated with lymph node metastasis in oral squamous cell carcinoma. PMID: 26700817
Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. PMID: 24769558
High ANXA8 expression is associated with pancreatic cancer. PMID: 23001853
Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring. PMID: 21344395
Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer PMID: 16203777
binds Ca2+-dependently and with high specificity to phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P2) and is also capable of interacting with F-actin PMID: 16638567
Data suggest that defective transport through the late endocytic pathway and imbalanced signaling in the absence of annexin A8 results from disturbed association of late endosomal membranes with actin and impaired endosome motility. PMID: 18923148

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Protein Families

Annexin family

Database Links

HGNC: 546

OMIM: 602396

KEGG: hsa:653145

STRING: 9606.ENSP00000341674

UniGene: Hs.535306

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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