ATP4B Antibody

Code CSB-PA002343GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
ATP4B
Alternative Names
Gastric H(+)/K(+) ATPase subunit beta antibody; ATP4B antibody; ATP4B_HUMAN antibody; ATP6B antibody; ATPase H+/K+ exchanging beta polypeptide antibody; ATPase H+/K+ transporting beta polypeptide antibody; Gastric H K ATPase catalytic subunit antibody; Gastric H(+)/K(+) ATPase subunit beta antibody; Gastric H+/K+ ATPase beta subunit antibody; Gastric hydrogen potassium ATPase antibody; Gastric hydrogen potassium ATPase beta antibody; Hydrogen/potassium exchanging ATPase 4B antibody; OTTHUMP00000178856 antibody; Parietal cell antigen antibody; Potassium transporting ATPase beta chain antibody; Potassium transporting ATPase subunit beta antibody; Potassium-transporting ATPase subunit beta antibody; Proton pump antibody; Proton pump beta chain antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human ATP4B
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle.
Gene References into Functions
  1. these findings demonstrated that a decrease in pHi, caused by H+/K+-ATPase inhibition induced by BMT-1, triggered the dysfunction of the mitochondria resulting in the apoptosis of MM cells PMID: 24700195
  2. Downregulation of ATP4B gene is associated with gastric cancer. PMID: 23317218
  3. BCL-2 inhibits formation of reactive oxygen species. PMID: 11865975
  4. Content of the beta1 subunit of sodium potassium pump in resistance trained control subjects was 33% higher in trained compared to untrained leg, and 47% higher in trained compared to untrained leg in diabetics. PMID: 14685860
  5. Thus prolonged exhaustive exercise impaired each of the maximal in vitro Na+-K+-ATPase activity, Ca2+ release, and Ca2+ uptake rates. PMID: 15155714
  6. Use of fold recognition methods enables the prediction that a C-terminal domain of the beta subunits of Na,K-ATPase and H,K-ATPase has an immunoglobulin-like fold, which resembles cell adhesion molecules. PMID: 19694409

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Subcellular Location
Apical cell membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein.
Protein Families
X(+)/potassium ATPases subunit beta family
Database Links

HGNC: 820

OMIM: 137217

KEGG: hsa:496

STRING: 9606.ENSP00000334216

UniGene: Hs.434202

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