CEP57 Antibody

Datasheet

Code	CSB-PA095230
Size	US$297
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Image	Western blot analysis of extracts from LOVO cells and COLO cells, using MRPS7 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CEP57 Polyclonal antibody

Uniprot No.

Q86XR8

Target Names

CEP57

Alternative Names

Centrosomal protein 57kDa antibody; Centrosomal protein of 57 kDa antibody; Cep57 antibody; Cep57 protein antibody; CEP57_HUMAN antibody; FGF2 interacting protein antibody; FGF2-interacting protein antibody; KIAA0092 antibody; MVA2 antibody; PIG8 antibody; Proliferation inducing protein 8 antibody; Testis specific protein 57 antibody; Testis-specific protein 57 antibody; Translokin antibody; TSP57 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from internal of Human CEP57.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.

Gene References into Functions

Cep57 is a mitotic kinetochore component that links the function of the KMN (KNL1/Mis12 complex/Ndc80 complex) network and spindle assembly checkpoint via Mis12 binding and Mad1-Mad2 interaction. PMID: 26743940
We identified copy number variation (CNV) deletion impacting the exon sequences of CEP57L1, present in the affected mother and her affected daughter PMID: 26561035
Cep57, Cep63, and Cep152 are parts of a ring-like complex localizing around the proximal end of centrioles. PMID: 23333316
Cep57 is essential for cytokinesis via regulation of central spindle assembly and formation of the midbody PMID: 23569207
Data suggest for therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. PMID: 23243019
Cep57 acts as a PCM component through binding to NEDD1 and is required for spindle microtubule organization and maintenance of spindle pole integrity. PMID: 22508265
Our findings indicate that these and/or additional functions of CEP57 are crucial for maintaining correct chromosomal number during cell division. PMID: 21552266

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Involvement in disease

Mosaic variegated aneuploidy syndrome 2 (MVA2)

Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein Families

Translokin family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 30794

OMIM: 607951

KEGG: hsa:9702

STRING: 9606.ENSP00000317902

UniGene: Hs.101014

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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