CMTM3 Antibody

Datasheet

Code	CSB-PA574353
Size	US$297
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Image	Western blot analysis of extracts from Jurkat cells and COS cells, using CKLF3 antibody.
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CMTM3 Polyclonal antibody

Uniprot No.

Q96MX0

Target Names

CMTM3

Alternative Names

CMTM3; CKLFSF3; CKLF-like MARVEL transmembrane domain-containing protein 3; Chemokine-like factor superfamily member 3

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from N-terminal of Human CKLF3.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Gene References into Functions

CMTM3 exhibited a lower expression pattern in gastric cancer tissues.MiR-135b-5p promotes gastric cancer progression by targeting CMTM3. PMID: 29345297
this study demonstrates that knockdown of CMTM3 promotes the metastasis of gastric cancer through the STAT3/Twist1/EMT pathway PMID: 27121055
CMTM3 was significantly hypermethylated in colorectal cancer tissues when compared with adjacent normal colorectal tissues. PMID: 28782576
CMTM3 decreases EGFR expression, facilitates EGFR degradation, and inhibits the EGF-mediated tumorigenicity of gastric cancer cells by enhancing Rab5 activity. PMID: 27867015
CMTM3 mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting by regulation VE-cadherin turnover. PMID: 28428220
Overexpression of CMTM3 attenuated the tumor growth of hepatocellular carcinoma. PMID: 27629543
identified CMTM3 as a novel secretory protein released via exosomes in the prostate PMID: 27125975
study indicates that elevated CMTM3 methylation is a risk factor in male LSCC patients, especially in the patients with age over 55years and with smoking behavior PMID: 27521994
Reduced expression of CMTM3 is associated with prostate cancer. PMID: 25990505
Low expression of CMTM3 was associated with metastasis and recurrence of oral squamous cell carcinoma. PMID: 25946973
CMTM3 is significantly down-regulated in clear cell renal cell carcinoma and exerts remarkable tumor-suppressive functions PMID: 23907292
Peritoneal disseminated metastases were significantly suppressed by CMTM3. PMID: 24131472
CMTM3/CKLFSF3 is an evolutionarily conserved gene that may have important roles in the male reproductive system and immune system. PMID: 17002874
CMTM3 inhibits prostate-specific antigen expression at both mRNA and protein levels with no obvious influence on androgen receptor expression. PMID: 18402773

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

Chemokine-like factor family

Tissue Specificity

Expressed in the leukocytes, placenta and testis.

Database Links

HGNC: 19174

OMIM: 607886

KEGG: hsa:123920

STRING: 9606.ENSP00000354579

UniGene: Hs.298198

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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