CPEB4 Antibody

Code CSB-PA618177LA01HU
Size US$166
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Image
  • Immunofluorescence staining of Hela cells with CSB-PA618177LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

  • Western blot
    All lanes: CPEB4 antibody at 2µg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: 293T whole cell lysate
    Lane 3: U87 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 81, 79, 37 kDa
    Observed band size: 81 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CPEB4 Polyclonal antibody
Uniprot No.
Target Names
CPEB4
Alternative Names
CPE binding protein 4 antibody; CPE-binding protein 4 antibody; CPE-BP4 antibody; cpeb4 antibody; CPEB4_HUMAN antibody; Cytoplasmic polyadenylation element binding protein 4 antibody; Cytoplasmic polyadenylation element-binding protein 4 antibody; hCPEB-4 antibody; KIAA1673 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cytoplasmic polyadenylation element-binding protein 4 protein (244-515AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CPEB4 Antibody (Product code: CSB-PA618177LA01HU) is Non-conjugated. For CPEB4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA618177LB01HU CPEB4 Antibody, HRP conjugated ELISA
FITC CSB-PA618177LC01HU CPEB4 Antibody, FITC conjugated
Biotin CSB-PA618177LD01HU CPEB4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation. Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes. In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory.
Gene References into Functions
  1. Silencing of CPEB4 induces reactive oxygen species generation, thus suppressing the Akt expression, which finally prevents non-small cell lung cancer cells invasion and migration. PMID: 29286212
  2. This study identified a lineage-specific requirement of CPEB4 in malignant melanoma. PMID: 27857118
  3. Survival analysis revealed a significant association between progression free survival (PFS) and overall survival (OS) and CPEB4 immunohistochemical expression, which was independent in the multivariate analysis. CPEB4 behaves as a significant predictor of prognosis in stage IV colorectal carcinoma. PMID: 28551384
  4. The results implicate the potential role of CPEB4 and Vimentin in breast cancer metastasis, which is further confirmed by the finding that there is a physical interaction between the two proteins. PMID: 28536077
  5. CPEB4 and IRF4 expression in peripheral mononuclear cells are potential prognostic factors for advanced lung cancer PMID: 27113098
  6. downregulation of CPEB4 likely occurs at the late cancer stage to facilitate HCC progression. Biphasic alteration of CPEB4 expression during HCC progression suggests its complicated role in tumorigenesis PMID: 27158894
  7. positive cytoplasmic polyadenylation element binding protein 4 expression predicted a worse prognosis in glioma patients, and cytoplasmic polyadenylation element binding protein 4 could represent a useful biomarker or therapeutic target for glioma. PMID: 28381179
  8. high expression of CPEB4 was found to be an independent prognostic biomarker for overall survival in colorectal cancer patients PMID: 27771769
  9. Our studies first validated that CPEB4 interacts with Vimentin and indicated that high CPEB4 expression in astrocytic tumors correlates closely with a clinically aggressive future, and that CPEB4 might represent a valuable prognostic marker for patients with astrocytic tumors. PMID: 26546435
  10. Low CPEB4 expression and high CPEB1 expression were independent predictors of overall survival in glioma patients. PMID: 27000226
  11. findings imply that posttranscriptional deregulation of CPEB4 contributes to the inhibited cell proliferation and the enhanced cell apoptosis in colorectal cancer, and directly targeting CPEB4 by miR-203 might be a strategy in colorectal cancer treatment PMID: 26361147
  12. Evidence that CPEB4 uses both its RNA recognition motifs to maintain optimal RNA binding. PMID: 25081215
  13. CPEB4 is a candidate biomarker for defining metastatic cancers and directing personalized therapies. PMID: 24045092
  14. Knockdown of CPEB4 expression significantly facilitated HCC cell migration and invasion. PMID: 23145039
  15. CPEB4, an RNA binding protein that mediates meiotic mRNA cytoplasmic polyadenylation and translation, is overexpressed in pancreatic ductal adenocarcinomas and glioblastomas, where it supports tumor growth, vascularization and invasion. PMID: 22138752

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Subcellular Location
Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell projection, axon. Cell projection, growth cone. Endoplasmic reticulum. Cytoplasm, perinuclear region.
Protein Families
RRM CPEB family
Tissue Specificity
Expressed in pancreas in islets and ductal cells (at protein level). Expressed in melanocytes.
Database Links

HGNC: 21747

OMIM: 610607

KEGG: hsa:80315

STRING: 9606.ENSP00000265085

UniGene: Hs.127126

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