CRCP Antibody

1. data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine PMID: 27155150
2. CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq/11 pathways. PMID: 27566546
3. In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed. PMID: 25015815
4. This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level PMID: 22074408
5. The extracellular protein domains corresponding to residues 23-133 of calcitonin receptor-like receptor and residues 26-117 of receptor activity-modifying protein 1 (RAMP1) are shown to be sufficient for formation of a stable, folded monodisperse complex. PMID: 20099900
6. Expression of CGRP-RCP was detected in CD34+ cells and also in some mature granulocyte samples, providing evidence that CGRP-RCP may be regulated independently of RAMP1 and CRLR in hematopoietic cells. PMID: 11937264
7. human CGRP-RCP is the genuine orthologue of C17. CGRP-RCP was found to functionally replace C17 in Deltarpc17 yeast cells; CGRP-RCP was identified in a purified human Pol III preparation. PMID: 12482973
8. inhibition of ACE seems to augment CGRP catabolism. PMID: 16406141
9. Increased mRNA expression CGRP-RCP in gravid myometrium supports the possibility of involvement of CGRP in the control of myometrial contractility. PMID: 17853344
10. A peptide mimetic demonstrates that 12 residues of family B member CGRP receptor proximal C-terminus are required for this receptor's expression and localization at the cell membrane. PMID: 18636754
11. analysis of the effects of antagonists to the CGRP receptor PMID: 19053766

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HGNC: 17888

OMIM: 606121

KEGG: hsa:27297

STRING: 9606.ENSP00000378736

UniGene: Hs.300684