Ctsk Antibody

Code CSB-PA006192LA01RA
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006192LA01RA at dilution of 1:20
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Ctsk Polyclonal antibody
Uniprot No.
Target Names
Ctsk
Alternative Names
Ctsk antibody; Cathepsin K antibody; EC 3.4.22.38 antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Recombinant Rat Cathepsin K protein (115-329AA)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated

The Ctsk Antibody (Product code: CSB-PA006192LA01RA) is Non-conjugated. For Ctsk Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA006192LB01RA Ctsk Antibody, HRP conjugated ELISA
FITC CSB-PA006192LC01RA Ctsk Antibody, FITC conjugated
Biotin CSB-PA006192LD01RA Ctsk Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:10-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
Gene References into Functions
  1. the present study identified icariin as a novel therapeutic agent in DXM-induced cartilage injury in rats, and revealed that the activation of miR-206 targeting of cathepsin K may be responsible for the chondroprotective efficacy of icariin PMID: 29207029
  2. cathepsin K, in both its secreted and lysosomal forms, may play a role in the degradation of Sertoli cell residual bodies PMID: 14585819
  3. In conclusion, according to its ability to modulate hypotensive effects of kinins, we propose that cathepsin K is a kininase of biological relevance. PMID: 17181996
  4. Comparison of the S2 site between rat and human cathepsin K sequences indicated that two S2 residues at Ser134 and Val160 in rat are varied to Ala and Leu, respectively, in the human enzyme. PMID: 18664521
  5. The expression pattern of Ctsk in osteoclasts in physiological root resorption in the rat molar was determined. PMID: 18974601

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Subcellular Location
Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side.
Protein Families
Peptidase C1 family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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