DHTKD1 Antibody

Code CSB-PA842685ESR1HU
Size US$166
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  • Western blot
    All lanes: DHTKD1 antibody at 1.82µg/ml
    Lane 1: Mouse heart tissue
    Lane 2: A431 whole cell lysate
    Lane 3: MCF-7 whole cell lysate
    Lane 4: HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 103 kDa
    Observed band size: 103 kDa

  • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA842685ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA842685ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DHTKD1 Polyclonal antibody
Uniprot No.
Target Names
DHTKD1
Alternative Names
AMOXAD antibody; CMT2Q antibody; Dehydrogenase E1 and transketolase domain containing 1 antibody; Dehydrogenase E1 and transketolase domain containing protein 1 antibody; Dehydrogenase E1 and transketolase domain-containing protein 1 antibody; DHTK1_HUMAN antibody; dhtkd1 antibody; DKFZp762M115 antibody; KIAA1630 antibody; MGC3090 antibody; Probable 2 oxoglutarate dehydrogenase E1 component DHKTD1 mitochondrial antibody; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1; mitochondrial antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial protein (1-280AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene References into Functions
  1. DHTKD1 encodes the E1 subunit of the alpha-ketoadipic acid dehydrogenase complex PMID: 25860818
  2. DHTKD1 contributes to mitochondrial biogenesis and function maintenance. PMID: 24076469
  3. DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria. PMID: 23141293
  4. A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. PMID: 23141294
Involvement in disease
Charcot-Marie-Tooth disease 2Q (CMT2Q); 2-aminoadipic 2-oxoadipic aciduria (AMOXAD)
Subcellular Location
Mitochondrion.
Protein Families
Alpha-ketoglutarate dehydrogenase family
Database Links

HGNC: 23537

OMIM: 204750

KEGG: hsa:55526

STRING: 9606.ENSP00000263035

UniGene: Hs.104980

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