DIAPH2 Antibody

Datasheet

Code	CSB-PA006891ESR1HU
Size	US$166
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Image	Western blot All lanes: DIAPH2 antibody at 4.75μg/ml Lane 1: 293T whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 126, 125 kDa Observed band size: 126 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006891ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA006891ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DIAPH2 Polyclonal antibody

Uniprot No.

O60879

Target Names

DIAPH2

Alternative Names

Dia 2 antibody; DIA antibody; Dia drome antibody; Dia2 antibody; Diap 2 antibody; Diap2 antibody; DIAP2_HUMAN antibody; DIAPH 2 antibody; Diaph2 antibody; Diaphanous 2 antibody; Diaphanous homolog 2 (Drosophila) antibody; Diaphanous homolog 2 antibody; Diaphanous related formin 2 antibody; Diaphanous-related formin-2 antibody; Diaphanous2 antibody; Diaphorase 2 antibody; Diaphorase2 antibody; DRF 2 antibody; DRF2 antibody; FLJ11167 antibody; OTTHUMP00000024270 antibody; OTTHUMP00000024271 antibody; OTTHUMP00000062171 antibody; POF 2 antibody; POF antibody; POF2 antibody; Protein diaphanous homolog 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein diaphanous homolog 2 protein (1-120AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.

Gene References into Functions

Low DIA2 expression is associated with breast cancer. PMID: 29596520
DIAPH2 has been associated with premature ovarian insufficiency, an aging phenotype in humans. PMID: 24037343
In podocytes, INF2 appears to be an important modulator of actin-dependent behaviors that are under the control of Rho/mDia signaling. PMID: 23620398
Dia2 and DIP co-tether to nascent blebs and this linkage is required for bleb formation. PMID: 23024796
Long HIV filopodial formation in infected dendritic cells was dependent on the formin diaphanous 2 (Diaph2) PMID: 22685410
Our results indicated that DIAPH2 may be a polygenic pleiotropy for premature ovarian failure (POF) and AMD. PMID: 21386871
Dia2 plays an important role in formation of lamellipodia. PMID: 18044991

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Involvement in disease

Premature ovarian failure 2A (POF2A)

Subcellular Location

[Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.

Protein Families

Formin homology family, Diaphanous subfamily

Tissue Specificity

Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.

Database Links

HGNC: 2877

OMIM: 300108

KEGG: hsa:1730

STRING: 9606.ENSP00000321348

UniGene: Hs.226483

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Regulation of actin cytoskeleton

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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