DTX2 Antibody

Code CSB-PA803123ESR2HU
Size US$166
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Image
  • Western blot
    All lanes: DTX2 antibody at 1μg/ml + HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 68, 63 kDa
    Observed band size: 68, 92 kDa

  • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA803123ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DTX2 Polyclonal antibody
Uniprot No.
Target Names
DTX2
Alternative Names
Deltex 2 antibody; deltex homolog 2 (Drosophila) antibody; deltex; Drosophila; homolog of; 2 antibody; Deltex2 antibody; DTX2 antibody; DTX2_HUMAN antibody; hDTX2 antibody; Highly similar to hPMSR6 [H.sapiens] antibody; KIAA1528 antibody; Probable E3 ubiquitin-protein ligase DTX2 antibody; Protein deltex 2 antibody; Protein deltex-2 antibody; RING finger protein 58 antibody; RNF58 antibody; Zinc ion binding protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Probable E3 ubiquitin-protein ligase DTX2 protein (1-280AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Gene References into Functions
  1. DTX2 is a gene encoding a WWE-RING-finger protein and involved in regulating heart development and heart functions. PMID: 17286044
  2. It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination. PMID: 12670957
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Deltex family
Database Links

HGNC: 15973

OMIM: 613141

KEGG: hsa:113878

STRING: 9606.ENSP00000322885

UniGene: Hs.187058

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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