ECT2 Antibody

1. High ECT2 expression was correlated with tumor metastasis and poor overall survival of osteosarcoma patients. PMID: 28794404
2. The expression of ECT2 is related to the survival of patients with breast cancer, and Its high expression is significantly associated with unfavourable survival rates. PMID: 29051317
3. These results identified p53 as a novel up-stream signaling molecule of ECT2 in Gastric cancer cells. PMID: 28654632
4. High PDC2 expression is associated with pancreatic adenocarcinoma. PMID: 26993610
5. While the association of ECT2 with the plasma membrane is essential for cytokinesis, our data suggest that ECT2 recruitment to the spindle midzone is insufficient to account for equatorial furrowing and may act redundantly with yet-uncharacterized signals. PMID: 27926870
6. Among 518 genes co-expressed with ECT2 in LUAD and 386 genes co-expressed with ECT2 in LUSC, there were only 98 genes in the overlapping cluster PMID: 29088286
7. E6AP suppresses breast cancer metastasis by regulating actin cytoskeleton remodeling through the control of ECT2 and Rho GTPase activity. PMID: 27231202
8. Ect2 regulates rRNA synthesis through a PKCiota-Ect2-Rac1-NPM signaling axis that is required for lung tumorigenesis. PMID: 28110998
9. Data suggest that the expression of epithelial cell transforming sequence 2 oncogene (ECT2) can serve as an alternative measurement that can compensate for the inadequacy of the current carcinoembryonic antigen (CEA) test in the diagnosis and monitoring of colorectal cancer patients. PMID: 28362321
10. Our data demonstrate that the cytokinetic proteins epithelial cell transforming 2 and Aurora kinase B (AurkB) are localized to stress granules in human astrocytoma cells PMID: 27106762
11. Kaplan-Meier analysis revealed that lower levels of Ect2 mRNA predicted higher overall survivals and biochemical recurrence (BCR)-free survivals in all patients or non-metastatic patients. PMID: 28012134
12. Our results suggest that ECT2 plays an important role during gastric cancer progression PMID: 26497353
13. Colorectal cancer patients with high expression levels of ECT2 had shorter overall survival. PMID: 26211594
14. ECT2 can crosstalk with RACGAP1 to catalyse the GTP exchange involved in Rho signalling to further regulate tumour initiation and metastasis. PMID: 25617497
15. Up-regulation of ECT2 might contribute to the progression of gastric carcinogenesis and may be a useful prognostic indicator in gastric cancer. PMID: 25674238
16. Poly(ADP-ribosyl)ation is recognized by ECT2. PMID: 25486481
17. central spindle assembly and 2 Plk1-dependent phosphorylations are required to establish efficient binding of the Ect2 BRCT in early cytokinesis. PMID: 25486482
18. ECT2 expression is positively correlated with WHO pathologic grading and unfavorable survival, suggesting that ECT2 may be a potential therapeutic candidate in human gliomas. PMID: 25237947
19. structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4 PMID: 25068414
20. the deregulation of miR-223 and its target gene ECT2 may be associated with the aggressive tumor progression of human osteosarcoma PMID: 24784921
21. Abnormality of the ECT2 gene occurs at a relatively early stage of lung adenocarcinogenesis and would be applicable as a new biomarker for prognostication of patients with lung adenocarcinoma PMID: 24484057
22. Both Pbl and ECT2 repress Wg/Wnt target gene expression in cultured Drosophila and human cells. PMID: 24198276
23. Data suggest that ECT2 may play an oncogenic role in the pancreatic ductal adenocarcinoma (PDAC) neoplastic process. PMID: 23851435
24. miR-223 functions as a tumor suppresser in osteosarcoma and miR-223/Ect2/p21 signaling is an important pathway that regulates the osteosarcoma cell cycle progression and proliferaion PMID: 23601845
25. ECT2 is important for tight junction function and maintenance of cell polarity. Nonfunction of this gene may cause renal tubulointerstitial injury, progressing to glomerular sclerosis. PMID: 22552385
26. RASAL2 was identified as an ECT2-interacting protein that regulates RHO activity in astrocytoma cells. PMID: 22683310
27. find that Ect2 first becomes active in prophase, when it is exported from the nucleus into the cytoplasm, activating RhoA to induce the formation of a mechanically stiff and rounded metaphase cortex PMID: 22898780
28. Data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex. PMID: 22514687
29. identify Ect2 as a cell cycle-regulated protein and suggest that its ubiquitination-dependent degradation may play an important role in RhoA regulation at the time of mitosis. PMID: 21886810
30. targeting of Ect2 to the equatorial membrane represents a key step in the delivery of the cytokinetic signal to the cortex PMID: 22172673
31. A mechanism involving the nuclear GEFs Ect2 and Net1 for activating RhoB after genotoxic stress, thereby facilitating cell death after treatment with DNA damaging agents. PMID: 21373644
32. Ect2 was a possible regulator of matrix-contact-side localization of invadopodia-related proteins. PMID: 21474972
33. a model in which PKCiota-mediated phosphorylation regulates Ect2 binding to the oncogenic PKCiota-Par6 complex thereby activating Rac1 activity and driving transformed growth and invasion. PMID: 21189248
34. Results suggest that ECT2 is an indicator of cellular proliferation in OSCCs and that ECT2 might be a potential therapeutic target for the development of new treatments for OSCCs. PMID: 21124766
35. XRCC1, CLB6, and BRCT domains of ECT2 play a critical role in regulating cytokinesis PMID: 14587037
36. ECT2 regulates the polarity complex Par6/Par3/PKCzeta and possibly plays a role in epithelial cell polarity PMID: 15254234
37. BRCT domains negatively regulate Ect2 GEF activity in interphase cells, and they are also required for the proper function of Ect2 during cytokinesis PMID: 15545273
38. Ect2 regulates the activation and function of Cdc42 in mitosis. PMID: 15642749
39. Central spindle localization of ECT2 assists division plane positioning and the CYK-4 subunit of centralspindlin acts upstream of RhoA to promote furrow assembly. PMID: 16103226
40. Cdk1 inactivation is sufficient to activate a signaling pathway leading to cytokinesis, which emanates from mitotic spindles and is regulated by ECT2, MgcRacGAP, and RhoA PMID: 16118207
41. MgcRacGAP controls the initiation of cytokinesis by regulating ECT2, which in turn induces the assembly of the contractile ring and triggers the ingression of the cleavage furrow PMID: 16129829
42. a conformational change of ECT2 upon phosphorylation at T341. Therefore, ECT2 activity might be regulated by the phosphorylation status of T341. PMID: 16170345
43. ECT2 is regulated by Plk1 and CDK1, phosphorylation of ECT2 leads to accumulation of RHOA PMID: 16247472
44. Data show that RhoA accumulates at the equatorial cortex before furrow initiation and continues to concentrate at the cleavage furrow during cytokinesis, and that centralspindlin and ECT2 are required for this localization and furrowing. PMID: 16352658
45. ECT2 knockdown triggers cell cycle arrest in G1. PMID: 16778203
46. In mitotic cells Ect2 localizes to the central spindle and to the cell cortex. PMID: 16803869
47. Aberrant ECT2 expression, observed in various human tumors, could be the direct result of RB/E2F pathway deficiency, thereby contributing to cell division in cancers. PMID: 16862181
48. Late mitotic Plk1 activity promotes recruitment of Ect2 to the central spindle, triggering the initiation of cytokinesis and contributing to cleavage plane specification in human cells. PMID: 17488623
49. This gene was silenced. PMID: 17688947
50. These results suggest that equatorial Ect2 locally suppresses lamellipodia formation via RhoA activation, which indirectly contributes to restricting lamellipodia formation to polar regions during cytokinesis B. PMID: 17942602

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HGNC: 3155

OMIM: 600586

KEGG: hsa:1894

STRING: 9606.ENSP00000232458

UniGene: Hs.518299