EIF2B3 Antibody

Datasheet

Code	CSB-PA002287
Size	US$100
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Image	Western Blot analysis of K562 cells using eIF2Bγ Polyclonal Antibody Western Blot analysis of K562 cells using eIF2Bγ Polyclonal Antibody
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9NR50

Target Names

EIF2B3

Alternative Names

EI2BG_HUMAN antibody; EIF 2B antibody; eIF 2B GDP GTP exchange factor subunit gamma antibody; eIF-2B GDP-GTP exchange factor subunit gamma antibody; eIF2B-gamma antibody; Eif2b3 antibody; EIF2Bgamma antibody; Eukaryotic translation initiation factor 2B subunit 3 gamma antibody; Eukaryotic translation initiation factor 2B; gamma antibody; eukaryotic translation initiation factor 2B; subunit 3 gamma; 58kDa antibody; OTTHUMP00000010262 antibody; OTTHUMP00000010263 antibody; Translation initiation factor eIF-2B subunit gamma antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human eIF2Bγ.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Gene References into Functions

To determine the tolerance differences to ERS, cell viability and apoptosis rates were detected in oligodendrocyte cell lines transfected with EIF2B3-c.1037T>C or the wild type. We confirmed that oligodendrocytes with mutant EIF2B3 was less tolerant to ERS than the wild type, with decreased cell viability and increased apoptosis rates. PMID: 26625702
Results show significant higher incidence of Chinese patients with EIF2B3 mutations compared with Caucasian patients. The c.1037T>C in EIF2B3 was confirmed to be a founder mutation in Chinese explaining the genotypic differences between ethnicities. PMID: 25761052

Involvement in disease

Leukodystrophy with vanishing white matter (VWM)

Protein Families

EIF-2B gamma/epsilon subunits family

Database Links

HGNC: 3259

OMIM: 603896

KEGG: hsa:8891

STRING: 9606.ENSP00000353575

UniGene: Hs.533549

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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