EMP1 Antibody

1. The abnormal expression of EMP-1 may be associated with progression of laryngeal carcinoma (LC) and the gene may act as a prognostic marker for LC. PMID: 28779068
2. The studies implicating GAS3 protein family (EMP1, EMP2, EMP3 and PMP22) in cancer pathogenesis as well as probe the structural similarities between the family members were highlighted. PMID: 27279240
3. Therefore, EMP1 is a tumor suppressor in laryngeal carcinoma. Boosting EMP1 expression in laryngeal carcinoma initiates multiple anticancer phenotypes and thus presents a promising therapeutic strategy for laryngeal cancer. PMID: 27909719
4. SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.EMP1 localises to tight junctions and is essential for their formation and function. PMID: 25394671
5. Low EMP1 expression in colorectal cancer is associated with increased disease severity, suggesting that EMP1 may be a negative regulator of colorectal cancer PMID: 24744589
6. Results demonstrated that EMP1 protein levels were significantly reduced in gastric carcinoma and were associated with tumor invasion, lymph node metastasis, clinical stage and cell differentiation. PMID: 24920167
7. EMP1 as an independent predictor for poor outcome in precursor-B ALL (BCP-ALL) (P=0.004, hazard ratio: 2.36 (1.31-4.25). PMID: 24625531
8. EMP-1 was significantly up-regulated in NSCLC patients. PMID: 23271282
9. EMP1 expression decreased in prostate cancer and correlated significantly T stages, lymph node metastasis, clinic stage, and Gleason score PMID: 24338711
10. EMP1 could be a biomarker for aberrant epithelial remodelling and metaplasia in chronic inflammatory upper airway mucosa PMID: 24033346
11. EMP1 may play important roles as a negative regulator to nasopharyngeal cancer cell. PMID: 24292952
12. EMP1 may play important roles as a negative regulator to breast cancer MCF-7 cell by regulating the expression of caspase 9 and VEGFC protein. PMID: 24402572
13. Overexpression of EMP1 in spinal chondrocytes promotes cell proliferation and survival, alters cell morphology and cell cycle, reduces cell condensation, and inhibits cell hypertrophy. PMID: 21538935
14. The EMP1 gene may be implicated in the pathophysiology of MDD in the Japanese population. PMID: 21146590
15. Decreased expression of EMP1 was significantly correlated with clinical stage (p=0.002) and lymph node metastasis (p=0.044) of patients with oral squamous cell carcinoma and may be a tumor suppressor. PMID: 20980531
16. EMP-1 gene has some relationship with carcinogenesis of esophagus. PMID: 12451984
17. Overexpression of human EMP-1 gene can inhibit the proliferation of EC9706 cell with S phase arrested and G1 phase prolonged. EMP-1 may be one of regulators involved in cell signaling, cell communication and adhesion regulators. PMID: 12632483
18. role of the adhesion molecule, EMP-1, as a biomarker of gefitinib clinical resistance, and further suggests a probable cross-talk between this molecule and the epidermal growth factor receptor signaling pathway PMID: 16087880
19. We found expression of EMP-1 mRNA was higher in intractable epilepsy per the gene scanning, EMP-1 immunoreactivity was apparent in neurons of IE patients but not in the control group, and the expression of EMP-1 and EGFR occurred in the same neuron. PMID: 19288191

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HGNC: 3333

OMIM: 602333

KEGG: hsa:2012

STRING: 9606.ENSP00000256951

UniGene: Hs.719042