FOXRED1 Antibody

Datasheet

Code	CSB-PA822192ESR2HU
Size	US$166
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Image	Western blot All lanes: FOXRED1 antibody at 5.8µg/ml Lane 1: A549 whole cell lysate Lane 2: A431 whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: Hela whole cell lysate Lane 5: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 54, 31, 53 kDa Observed band size: 54 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822192ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA822192ESR2HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) FOXRED1 Polyclonal antibody

Uniprot No.

Q96CU9

Target Names

FOXRED1

Alternative Names

FOXRED1; FP634; FAD-dependent oxidoreductase domain-containing protein 1

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human FAD-dependent oxidoreductase domain-containing protein 1 protein (307-486AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.

Gene References into Functions

Results show that depletion of FOXRED1 in myoblasts results in decreased levels of fully assembled complexes I and II. FOXRED1 associates with the ND1-containing subcomplexes of ~370 kDa and ~620 kDa and that FOXRED1 activity is required for the formation of a 550-kDa subcomplex of complex I. PMID: 27215383
Loss of FOXRED1, coupled with protein, choline and/or folate-deficient diets results in the depletion of glutathione, the dysregulation of nitric oxide metabolism and the peroxynitrite-mediated inactivation of complex I. PMID: 26235939
A structural model of FOXRED1 reveals a large substrate-binding cavity and a putative oxygen-binding site. PMID: 25765152
FOXRED1 is a crucial component in the productive assembly of respiratory chain complex I and that mutations in FOXRED1 leading to partial loss of function cause defects in complex I biogenesis. PMID: 25678554
Mutations in FOXRED1 are associated with complex I deficiency. PMID: 20818383

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Involvement in disease

Mitochondrial complex I deficiency (MT-C1D)

Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein.

Database Links

HGNC: 26927

OMIM: 252010

KEGG: hsa:55572

STRING: 9606.ENSP00000263578

UniGene: Hs.317190

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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