GOT2 Antibody

1. Study utilizing integrative analysis of transcriptomic, metabolomic, and clinical data propose a model of GOT2 transcriptional regulation, in which the cooperative phosphorylation of STAT3 and direct joint binding of STAT3 and p65/NF-kappaB to the proximal GOT2 promoter are important. Furthermore, high aberrant GOT2 expression is prognostic in diffuse large B-cell lymphoma. PMID: 29666362
2. The results of our study on this larger than 5800-patient cohort suggest beneficial effects of high B12 vitamin level, negative effects of high sodium levels or high AST (aspartate aminotransferase) liver enzyme levels to cognition. PMID: 28918286
3. Like in adults, FABP seems to be associated with markers of metabolic risk in obese adolescents PMID: 28183455
4. Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT2 rises due to up-regulation of hepatic expression of GOT2 associated with greater gluconeogenesis and insulin resistance. PMID: 26791191
5. A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection. PMID: 25755250
6. High glucose infusion was associated with increased expression of higher plasma membrane-associated fatty acid-binding protein (FABPpm). PMID: 24937540
7. The lipid binding process in L-FABP is associated with backbone dynamics. PMID: 22713574
8. Frequency of polymorphism are similar in control groups and schizophrenics. PMID: 17728674

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HGNC: 4433

OMIM: 138150

KEGG: hsa:2806

STRING: 9606.ENSP00000245206

UniGene: Hs.599470