GOT2 Antibody

Datasheet

Code	CSB-PA03065A0Rb
Size	US$166
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Image	Western blot All lanes: GOT2 antibody at 3µg/ml Lane 1: A431 whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: Mouse muscle tissue Lane 4: Mouse spleen tissue Lane 5: MCF-7 whole cell lysate Lane 6: Hela whole cell lysate Lane 7: LO2 whole cell lysate Lane 8: 293T whole cell lysate Lane 9: HL60 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 48, 44 kDa Observed band size: 48 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA03065A0Rb at dilution of 1:100 Immunofluorescent analysis of MCF-7 cells using CSB-PA03065A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GOT2 Polyclonal antibody

Uniprot No.

P00505

Target Names

GOT2

Alternative Names

AATM_HUMAN antibody; AL022787 antibody; Aspartate aminotransferase 2 antibody; Aspartate aminotransferase antibody; Aspartate aminotransferase; mitochondrial antibody; Aspartate transaminase 2 antibody; ASPATA antibody; EC 2.6.1.1 antibody; FABP 1 antibody; FABP pm antibody; FABP-1 antibody; FABPpm antibody; Fatty acid binding protein antibody; Fatty acid-binding protein antibody; FLJ40994 antibody; Glutamate oxaloacetate transaminase 2 antibody; Glutamate oxaloacetate transaminase 2; mitochondrial antibody; Glutamate oxaloacetate transaminase; mitochondrial antibody; Glutamic oxaloacetic transaminase 2; mitochondrial (aspartate aminotransferase 2) antibody; Got 2 antibody; GOT2 antibody; KAT4 antibody; KATIV antibody; kynurenine aminotransferase 4 antibody; Kynurenine aminotransferase IV antibody; kynurenine--oxoglutarate transaminase 4 antibody; kynurenine--oxoglutarate transaminase IV antibody; mAspAT antibody; MGC102129 antibody; MGC115763 antibody; mitAAT antibody; mitochondrial antibody; Mitochondrial aspartate aminotransferase antibody; OTTMUSP00000017748 antibody; Plasma membrane fatty acid binding protein antibody; Plasma membrane-associated fatty acid-binding protein antibody; Transaminase A antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Aspartate aminotransferase, mitochondrial protein (33-279AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The GOT2 Antibody (Product code: CSB-PA03065A0Rb) is Non-conjugated. For GOT2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA03065B0Rb	GOT2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA03065C0Rb	GOT2 Antibody, FITC conjugated
Biotin	CSB-PA03065D0Rb	GOT2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids.

Gene References into Functions

Study utilizing integrative analysis of transcriptomic, metabolomic, and clinical data propose a model of GOT2 transcriptional regulation, in which the cooperative phosphorylation of STAT3 and direct joint binding of STAT3 and p65/NF-kappaB to the proximal GOT2 promoter are important. Furthermore, high aberrant GOT2 expression is prognostic in diffuse large B-cell lymphoma. PMID: 29666362
The results of our study on this larger than 5800-patient cohort suggest beneficial effects of high B12 vitamin level, negative effects of high sodium levels or high AST (aspartate aminotransferase) liver enzyme levels to cognition. PMID: 28918286
Like in adults, FABP seems to be associated with markers of metabolic risk in obese adolescents PMID: 28183455
Data suggest that, in context of abnormal hepatic lipid accumulation in nonalcoholic fatty liver disease, circulating GOT2 rises due to up-regulation of hepatic expression of GOT2 associated with greater gluconeogenesis and insulin resistance. PMID: 26791191
A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection. PMID: 25755250
High glucose infusion was associated with increased expression of higher plasma membrane-associated fatty acid-binding protein (FABPpm). PMID: 24937540
The lipid binding process in L-FABP is associated with backbone dynamics. PMID: 22713574
Frequency of polymorphism are similar in control groups and schizophrenics. PMID: 17728674

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Subcellular Location

Mitochondrion matrix. Cell membrane.

Protein Families

Class-I pyridoxal-phosphate-dependent aminotransferase family

Database Links

HGNC: 4433

OMIM: 138150

KEGG: hsa:2806

STRING: 9606.ENSP00000245206

UniGene: Hs.599470

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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