HDAC10 Antibody

Datasheet

Code	CSB-PA010236LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse liver tissue All lanes: HDAC10 antibody at 3.4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 72, 70, 71, 44 kDa Observed band size: 72, 34 kDa Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA010236LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA010236LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA010236LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Immunofluorescent analysis of MCF-7 cells using CSB-PA010236LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) HDAC10 Polyclonal antibody

Uniprot No.

Q969S8

Target Names

HDAC10

Alternative Names

DKFZP761B039 antibody; HD 10 antibody; HD10 antibody; HDA10_HUMAN antibody; HDAC 10 antibody; Hdac10 antibody; Histone deacetylase 10 antibody; MGC149722 antibody; OTTHUMP00000028555 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Histone deacetylase 10 protein (207-412AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The HDAC10 Antibody (Product code: CSB-PA010236LA01HU) is Non-conjugated. For HDAC10 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA010236LB01HU	HDAC10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA010236LC01HU	HDAC10 Antibody, FITC conjugated
Biotin	CSB-PA010236LD01HU	HDAC10 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.

Gene References into Functions

HDAC10 structure and molecular function as a polyamine deacetylase has been reported. PMID: 28516954
this study demonstrated that HDAC10 localizes and functions in the cytoplasm of lung cancer cells, thereby underscoring its potential role in the diagnosis and treatment of lung cancer PMID: 27449083
HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter. PMID: 26240284
study identifies an HDAC10-mediated regulatory mechanism controlling the DNA mismatch repair function of MSH2. PMID: 26221039
Suggest HDAC10 expression as a prognostic marker for gastric cancer. PMID: 25337229
this study is describing HDAC10 as a promoter of autophagy-mediated survival in neuroblastoma cells and identifying this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival. PMID: 24145760
HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis PMID: 23897811
results demonstrate that HDAC10 protects cancer cells from cytotoxic agents by mediating autophagy and identify this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival PMID: 23801752
Histone deacetylases 9 and 10 are required for homologous recombination. PMID: 21247901
HDAC10 is involved in transcriptional downregulation of TXNIP, leading to altered reactive oxygen species signaling in human gastric cancer cells. PMID: 20680488
Results not only show that HDAC10 regulates melanogenesis but also demonstrate that the transcriptional activities of Pax3 and KAP1 are intimately linked to their acetylation status. PMID: 20032463
another histone deacetylase PMID: 11739383
molecular cloning and characterization of a novel class II histone deacetylase PMID: 11861901
Reduced expression of histone deacetylase 10 is associated lung cancer PMID: 15305372
Results suggest that the "T" allele of HDAC10-589C>T affect on the increased transcription activity, and might accelerate HCC development through increased expression of HDAC10. PMID: 17892858

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Histone deacetylase family, HD type 2 subfamily

Tissue Specificity

Widely expressed with high levels in liver and kidney.

Database Links

HGNC: 18128

OMIM: 608544

KEGG: hsa:83933

STRING: 9606.ENSP00000216271

UniGene: Hs.26593

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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