HOXB5 Antibody

1. for the first time we have shown that knockdown of HOXB5 significantly inhibited non-small cell lung cancer cell proliferation, invasion, metastasis, and epithelial-mesenchymal transformation, partly through the Wnt/beta-catenin signaling pathway PMID: 28337958
2. Taken together, our results for the first time suggested that miR-455-3p was downregulated in NSCLC and was correlated with the poor prognosis of NSCLC patients. Also, miR-455-3p functions as tumor suppressor by directly targeting HOXB5 in NSCLC progression and may be used as a potential target for NSCLC treatment. PMID: 29170127
3. HOXB5 acts as a positive modulator by promoting cell proliferative response and invasiveness in ER-positive breast cancer. PMID: 25999793
4. HOXB5 may be an important regulator of the Wnt/beta-catenin signalling pathway, thereby contributing to gastric cancer progression and metastasis. PMID: 26467157
5. Roles of Hoxb5 in the development of vagal and trunk neural crest cells. PMID: 25703667
6. Overexpression of HoxB5 enhances blood vessel perfusion in vivo by up-regulation of MCP-1 and IL-6 as well as in enhanced leucocyte infiltration and blood vessel remodelling. PMID: 24189625
7. HOXB5 and HOXB8 are frequently expressed in ovarian serous carcinoma, with anatomic site-related differences for cytoplasmic staining. HOXB5 may be affected by chemotherapy in effusions. PMID: 23438671
8. The findings for HOXB5 and PHOX2B provide supportive evidence that genes regulating ENCC proliferation, migration and differentiation could be risk factors for Hirschsprung's disease PMID: 22648184
9. A miRNA 7-binding single nucleotide polymorphism (1010A/G) located within 3'-UTR of HOXB5 is associated with gene expression and may be a promising prognostic factor for bladder cancer. PMID: 22768238
10. HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia. PMID: 22603795
11. Single nucleotide polymorphism in HOXB5 gene is associated with childhood obesity. PMID: 22484627
12. results support that expression of HOX genes is associated with oral squamous cell carcinoma; over 90% of OSCC samples presented HOXB5 expression versus 60% of non-tumor tissues, it can be suggested that HOXB5 may be related to the malignant phenotypes. PMID: 21552713
13. Data show that human HOXB5 binds to the promoter region 5' upstream of the binding site of NKX2-1 and regulates RET expression. PMID: 21677782
14. HoxB5 is necessary and sufficient to activate the cell-intrinsic events that regulate the differentiation of angioblasts and mature endothelial cells from their mesoderm-derived precursors PMID: 12897140
15. The expression pattern of HOXB5 correlated with the migration and differentiation of neural crest cells. PMID: 12950074

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HGNC: 5116

OMIM: 142960

KEGG: hsa:3215

STRING: 9606.ENSP00000239151

UniGene: Hs.654456