HOXC4 Antibody

Code CSB-PA010675GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
HOXC4
Alternative Names
CP 19 antibody; CP19 antibody; Homeo box 3E antibody; Homeo box C4 antibody; Homeo box protein HoxC4 antibody; Homeobox 3E antibody; Homeobox C4 antibody; Homeobox protein CP19 antibody; Homeobox protein Hox C4 antibody; Homeobox protein Hox-3E antibody; Homeobox protein Hox-C4 antibody; Homeobox protein HoxC4 antibody; Homeobox3E antibody; HomeoboxC4 antibody; HOX 3 antibody; Hox 3E antibody; HOX C4 antibody; HOX3 antibody; Hox3E antibody; HOXC 4 antibody; Hoxc4 antibody; HXC4_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human HOXC4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Gene References into Functions
  1. HOXC4 homeoprotein expands human hematopoietic immature cells by 3 to 6 times ex vivo and significantly improves the level of in vivo engraftment. PMID: 22298821
  2. Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 in lymphocytic progenitor cells. PMID: 19236766
  3. Esr1 bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation. PMID: 20855884
  4. Selective inhibition of class switching to IgG and IgE by recruitment of this and Oct-1 proteins and Ku70/Ku86 to newly identified ATTT cis-elements. PMID: 12672812
  5. The hs1,2mediated enhancement of V(H) and C(H) promoter-driven transcription as induced by HoxC4 and Oct-1/Oct-2 suggests an important role of these homeodomain proteins in the overall regulation of the IgH locus expression. PMID: 15252056
  6. The HOXC4 expression was clearly detected in all inv(7) positive patients. PMID: 15674412
  7. HoxC4 directly activates the Aicda promoter PMID: 19363484

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family, Deformed subfamily
Database Links

HGNC: 5126

OMIM: 142974

KEGG: hsa:3221

STRING: 9606.ENSP00000305973

UniGene: Hs.549040

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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