HOXC4

The protein encoded by the gene HOXC4 is known as Homeobox C4, a member of the homeobox gene family. Commonly referred to as HOXC4, this protein functions as a transcription factor, playing a crucial role in the regulation of morphological development. HOXC4 is involved in hematopoiesis, where it expands hematopoietic immature cells and improves in vivo engraftment levels. It is associated with signaling pathways such as NF-κB, and its dysregulation has been linked to diseases like immunodeficiency and lymphoma. In terms of drug development, research has focused on the role of HOXC4 in promoting glycolysis in pancreatic cancer cells, suggesting potential therapeutic targets.