Product Details

Uniprot No.

Target Names

LAT2

Alternative Names

HSPC046 antibody; LAB antibody; LAT2 antibody; Linker for activation of B cells antibody; Linker for activation of B-cells antibody; Linker for activation of T cells family member 2 antibody; Linker for activation of T cells transmembrane adaptor 2 antibody; Linker for activation of T-cells family member 2 antibody; Membrane associated adapter molecule antibody; Membrane-associated adapter molecule antibody; Non T cell activation linker antibody; Non-T-cell activation linker antibody; NTAL_HUMAN antibody; WBSCR 5 antibody; Wbscr15 antibody; Williams Beuren syndrome chromosome region 15 antibody; Williams Beuren syndrome chromosome region 5 antibody; Williams-Beuren syndrome chromosomal region 15 protein antibody; Williams-Beuren syndrome chromosomal region 5 protein antibody; WSCR5 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human LAT2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.

Gene References into Functions

Its overexpression represents a negative prognostic marker that has been linked to tumor grade, proliferating potential and angiogenesis and mediates intracellular transport of anticancer agents. PMID: 28815339
The AML1/ETO target gene LAT2 interferes with differentiation of normal hematopoietic precursor cells. PMID: 24456692
LAT2 is an early mediator of the anti-leukemic activity of alkylphospholipids and arsenic trioxide. Thus, LAT2 may be used as a target for the design of drugs for cancer therapy. PMID: 23001822
NTAL acts as a tumor suppressor that enhances the proximal signaling of leukemic blasts. The key downstream molecule responsible for the biological effect of TCR signaling is ERK. PMID: 22269118
LAB has the ability to modulate signaling in virtually every type of leukocyte. PMID: 20643813
LAT2 protein (NTAL) participates in the activation of the c-Met-Grb2-ERK-cPLA2 signalling cascade at early stages of H. pylori infection. PMID: 19879355
data show that NTAL (non-T cell activation linker) appears to be a structural and possibly also functional homologue of LAT (linker for activation of T cells)in non-T cells [non-T cell activation linker] PMID: 12486104
LAB links BCR engagement to downstream signaling pathways. PMID: 12514734
LAB was primarily phosphorylated on three membrane-distal tyrosines, Tyr(136), Tyr(193), and Tyr(233). Mutation of these three tyrosines abolished Grb2 binding and LAB function PMID: 14722116
LAB resembled a LAT molecule unable to bind phospholipase C-gamma1. PMID: 15153499
The NTAL/LAB is expressed in a variety of immune cells. PMID: 15745852
NTAL acts as a negative regulator of TNF-alpha and IL-8 production after stimulation via TREM-1 PMID: 17277102
observations reported herein support the conclusion that NTAL may be differentially utilized by specific receptors for relaying alternative signals and this suggests a flexibility in the function of TRAPs not previously appreciated. PMID: 17993265
These data show that natural killer cell immunoreceptor tyrosine-based activation motifs preferentially use a signaling cassette regulated by interplay between LAT and LAB. PMID: 18645037
expression separates T lineage leukemias into two subgroups with good and poor prognostic outcome to prednisone therapy in acute lymphoblastic leukemia in children PMID: 19183565

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Involvement in disease

LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.

Subcellular Location

Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts.

Tissue Specificity

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).

Database Links

HGNC: 12749

OMIM: 605719

KEGG: hsa:7462

STRING: 9606.ENSP00000275635

UniGene: Hs.741249