MAEL Antibody

Datasheet

Code	CSB-PA842695LA01HU
Size	US$166
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Image	Immunofluorescence staining of Hela cells with CSB-PA842695LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA842695LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAEL Polyclonal antibody

Uniprot No.

Q96JY0

Target Names

MAEL

Alternative Names

cancer/testis antigen 128 antibody; CT128 antibody; FLJ14904 antibody; mael antibody; MAEL_HUMAN antibody; maelstrom homolog (Drosophila) antibody; Maelstrom homolog antibody; OTTHUMP00000032344 antibody; Protein maelstrom homolog antibody; RP11-102C16.1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein maelstrom homolog protein (1-200AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MAEL Antibody (Product code: CSB-PA842695LA01HU) is Non-conjugated. For MAEL Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA842695LB01HU	MAEL Antibody, HRP conjugated	ELISA
FITC	CSB-PA842695LC01HU	MAEL Antibody, FITC conjugated
Biotin	CSB-PA842695LD01HU	MAEL Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

Gene References into Functions

MAEL promoter hypermethylation may have a role in de-repression of LINE-1 in human hypospermatogenesis PMID: 29095993
Report found that Mael is activated in proliferating cancer cells, where it serves to maintain genetic stability. Its depletion results in an increase in reactive oxygen species, followed by apoptosis or senescence. PMID: 27926513
Data suggest that overexpression of MAEL, caused by gene amplification and/or decreased miR-186, has a critical oncogenic role in UCB pathogenesis by downregulation of MTSS1. PMID: 27181205
Study demonstrated that MAEL interacts with Snail and inhibit E-cadherin promoter activity. MAEL is an oncogene that plays an important role in the development and progression of colon cancer. PMID: 27537253
Immunofluorescence analysis showed that MAEL co-localizes with the stress granule marker PABPC1 in stress granules during oxidative stress. MAEL may be involved in miRNA-mediated gene silencing in SGs. PMID: 24189637
Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3beta/Snail signaling. PMID: 23929794
These results suggest that MAEL is a novel cancer/testis-associated gene and is regulated by DNA methylation. PMID: 19693694

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Maelstrom family

Tissue Specificity

Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.

Database Links

HGNC: 25929

OMIM: 611368

KEGG: hsa:84944

STRING: 9606.ENSP00000356846

UniGene: Hs.651245

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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