MAT2B Antibody

Datasheet

Code	CSB-PA882157LA01HU
Size	US$166
	Order now
Image	Immunofluorescent analysis of HepG2 cells using CSB-PA882157LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Western Blot Positive WB detected in: Rat heart tissue All lanes: MAT2B antibody at 4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 38, 37, 29, 35, 10 kDa Observed band size: 38 kDa
The Latest Promotion
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAT2B Polyclonal antibody

Uniprot No.

Q9NZL9

Target Names

MAT2B

Alternative Names

1110064C04Rik antibody; 2410018D16Rik antibody; AI182287 antibody; AU022853 antibody; Beta regulatory subunit of methionine adenosyltransferase antibody; dTDP 4 keto 6 deoxy D glucose 4 reductase antibody; DTDP-4-keto-6-deoxy-D-glucose 4-reductase antibody; MAT II antibody; MAT II beta antibody; Mat2b antibody; MAT2B_HUMAN antibody; MATIIbeta antibody; Methionine adenosyltransferase 2 beta subunit antibody; Methionine adenosyltransferase 2 subunit beta antibody; Methionine adenosyltransferase II beta antibody; MGC12237 antibody; MSTP045 antibody; Nbla02999 antibody; OTTMUSP00000005600 antibody; Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase antibody; Putative protein product of Nbla02999 antibody; RP23-382C18.2 antibody; SDR23E1 antibody; Short chain dehydrogenase/reductase family 23E member 1 antibody; TGR antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Methionine adenosyltransferase 2 subunit beta protein (85-143AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MAT2B Antibody (Product code: CSB-PA882157LA01HU) is Non-conjugated. For MAT2B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA882157LB01HU	MAT2B Antibody, HRP conjugated	ELISA
FITC	CSB-PA882157LC01HU	MAT2B Antibody, FITC conjugated
Biotin	CSB-PA882157LD01HU	MAT2B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:2000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function

Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).

Gene References into Functions

Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity. PMID: 27573889
Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway PMID: 25794709
Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation. PMID: 25294683
MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis. PMID: 23325601
The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR) core with specificity for the NADP/H cofactor, and harbors the SDR catalytic triad. PMID: 23425511
Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity. PMID: 21813468
Data show MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation. PMID: 20421296
Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells. PMID: 18041713
Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death. PMID: 18045590
a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B PMID: 18698677
differences in malignant cell survival, effected by MAT-IIbeta ablation, suggest that it may be possible to use this approach to disadvantage leukemic cell survival in vivo with little to no harm to normal cells. PMID: 18753136

Hide All

Protein Families

DTDP-4-dehydrorhamnose reductase family, MAT2B subfamily

Tissue Specificity

Widely expressed.

Database Links

HGNC: 6905

OMIM: 605527

KEGG: hsa:27430

STRING: 9606.ENSP00000325425

UniGene: Hs.54642

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Virus Infection

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Place an order now

I. Product details

Product name *

Code *

Size *

Quantity *

Message

II. Contact details

Name *

Email address *

Company/Organization

Phone

III. Ship To

Address *

City *

State/Province *

Zip/Post code *

Country *

Attn Name *

Phone# *

IV. Bill To Same as Shipping Address