MAT2B Antibody

1. Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity. PMID: 27573889
2. Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway PMID: 25794709
3. Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation. PMID: 25294683
4. MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis. PMID: 23325601
5. The structure of MAT2B reveals a short-chain dehydrogenase/reductase (SDR) core with specificity for the NADP/H cofactor, and harbors the SDR catalytic triad. PMID: 23425511
6. Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity. PMID: 21813468
7. Data show MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation. PMID: 20421296
8. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells. PMID: 18041713
9. Splicing variants of MAT2beta are up-regulated in hepatocellular carcinoma and regulated tumor cell growth and death. PMID: 18045590
10. a switch in MAT expression in liver cancer was accompanied by increasing expression of MAT2B PMID: 18698677
11. differences in malignant cell survival, effected by MAT-IIbeta ablation, suggest that it may be possible to use this approach to disadvantage leukemic cell survival in vivo with little to no harm to normal cells. PMID: 18753136

Show More

Hide All

HGNC: 6905

OMIM: 605527

KEGG: hsa:27430

STRING: 9606.ENSP00000325425

UniGene: Hs.54642