MC5R Antibody

Code CSB-PA013562LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA013562LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA013562LA01HU at dilution of 1:100

  • Immunofluorescence staining of MCF-7 cells with CSB-PA013562LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MC5R Polyclonal antibody
Uniprot No.
Target Names
MC5R
Alternative Names
MC5R; Melanocortin receptor 5; MC5-R; MC-2
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Melanocortin receptor 5 protein (1-37AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The MC5R Antibody (Product code: CSB-PA013562LA01HU) is Non-conjugated. For MC5R Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA013562LB01HU MC5R Antibody, HRP conjugated ELISA
FITC CSB-PA013562LC01HU MC5R Antibody, FITC conjugated
Biotin CSB-PA013562LD01HU MC5R Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
Gene References into Functions
  1. Mutations in residues S4/S5 and S17/E18 retained MC5R at the ER/Golgi complex and did not affect MC5R homodimerization. PMID: 28396017
  2. D115 and D119 in TM3, F195 in TM5, and F254 in TM6 may form a binding pocket for NDP-alpha-MSH binding. PMID: 23414113
  3. Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and beta-arrestins 1/2. PMID: 22871966
  4. Variations in the melanocortin 5 receptor gene are unlikely to confer susceptibility to bipolar disorder in this sample. PMID: 16314755
  5. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119 were made at MC5R. PMID: 17482720
  6. MC5R signals through a PI3K-regulated Akt-independent pathway leading to downstream activation of ERK1/2 PMID: 19428994

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Expressed in the brain but not in the melanoma cells.
Database Links

HGNC: 6933

OMIM: 600042

KEGG: hsa:4161

STRING: 9606.ENSP00000318077

UniGene: Hs.248145

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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