MC5R

Melanocortin 5 Receptor (MC5R), a G protein-coupled receptor (GPCR) in the melanocortin family, is often called MC5-R. It binds endogenous ligands like α-melanocyte-stimulating hormone (α-MSH) to activate the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway, regulating sebum secretion, energy homeostasis, and exocrine gland function.
Aberrant MC5R activity links to obesity, seborrheic dermatitis, and metabolic syndrome. Drug development focuses on selective modulators: agonists are explored for sebaceous disorders, while antagonists show potential in metabolic imbalances—most candidates remain in preclinical research stages.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

MC5R Antibody (CSB-PA013562LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human glioma using CSB-PA013562LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA013562LA01HU at dilution of 1:100

Immunofluorescence staining of MCF-7 cells with CSB-PA013562LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following MC5R reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MC5R Antibodies

MC5R Proteins

MC5R Antibodies

MC5R Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA003205	MC5R Antibody	Human,Mouse,Rat	WB, IF, ELISA
CSB-PA067089	MC5R Antibody	Human	ELISA,IHC
CSB-PA091719	MC5R Antibody	Human,Mouse	ELISA,WB
CSB-PA013562LA01HU	MC5R Antibody	Human	ELISA, IHC, IF
CSB-PA013562LB01HU	MC5R Antibody, HRP conjugated	Human	ELISA
CSB-PA013562LC01HU	MC5R Antibody, FITC conjugated	Human
CSB-PA013562LD01HU	MC5R Antibody, Biotin conjugated	Human	ELISA

MC5R Proteins

MC5R Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-CF863073PI	Recombinant Pig Melanocortin receptor 5 (MC5R)	in vitro E.coli expression system
CSB-YP863073PI1 CSB-EP863073PI1 CSB-BP863073PI1 CSB-MP863073PI1 CSB-EP863073PI1-B	Recombinant Pig Melanocortin receptor 5 (MC5R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MC5R Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-CF866132EQV	Recombinant Pan troglodytes Melanocortin receptor 5 (MC5R)	in vitro E.coli expression system
CSB-YP866132EQV1 CSB-EP866132EQV1 CSB-BP866132EQV1 CSB-MP866132EQV1 CSB-EP866132EQV1-B	Recombinant Pan troglodytes Melanocortin receptor 5 (MC5R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MC5R Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF013562RA	Recombinant Rat Melanocortin receptor 5 (Mc5r)	in vitro E.coli expression system
CSB-YP013562RA1 CSB-EP013562RA1 CSB-BP013562RA1 CSB-MP013562RA1 CSB-EP013562RA1-B	Recombinant Rat Melanocortin receptor 5 (Mc5r), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MC5R Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF013562MO	Recombinant Mouse Melanocortin receptor 5 (Mc5r)	in vitro E.coli expression system
CSB-YP013562MO1 CSB-EP013562MO1 CSB-BP013562MO1 CSB-MP013562MO1 CSB-EP013562MO1-B	Recombinant Mouse Melanocortin receptor 5 (Mc5r), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MC5R Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-CF013562SH	Recombinant Sheep Melanocortin receptor 5 (MC5R)	in vitro E.coli expression system
CSB-YP013562SH1 CSB-EP013562SH1 CSB-BP013562SH1 CSB-MP013562SH1 CSB-EP013562SH1-B	Recombinant Sheep Melanocortin receptor 5 (MC5R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MC5R Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF013562HU	Recombinant Human Melanocortin receptor 5 (MC5R)	in vitro E.coli expression system
CSB-YP013562HU1 CSB-EP013562HU1 CSB-BP013562HU1 CSB-MP013562HU1 CSB-EP013562HU1-B	Recombinant Human Melanocortin receptor 5 (MC5R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MC5R Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF013562BO	Recombinant Bovine Melanocortin receptor 5 (MC5R)	in vitro E.coli expression system
CSB-YP013562BO1 CSB-EP013562BO1 CSB-BP013562BO1 CSB-MP013562BO1 CSB-EP013562BO1-B	Recombinant Bovine Melanocortin receptor 5 (MC5R), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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MC5R

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